Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow ELISA Kit rightarrow TNFRSF13C rightarrow Human TNFRSF13C  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Collagen Type II Cleavage (C2C) ELISA Kit
 • TPP1 cDNA Clone
 • A Disintegrin And Metalloprotease 9 (ADAM9) ELISA Kit
 • pregnancy specific beta-1-glycoprotein 6 (PSG6) ELISA Kit
 • alkB, alkylation repair homolog 1 Antibody
 • THOC1 Antibody
 • ABCB9 Antibody
 • IgA 1&2 Antibody
 • Uncoupling Protein 1, Mitochondrial (UCP1) ELISA Kit
 • high sensitivity C-Reactive Protein (hs-CRP) ELISA Kit
 • HMGA1 Antibody
 • Vimentin ELISA Kit
 • Cluster Of Differentiation 4 (CD4) ELISA Kit
 • FOXP3 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

TNFRSF13C elisa kit :: Human CD268 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS824623
Typical Standard Curve/Testing Data
Unit / Price
96 Tests  /  $470 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD268 (TNFRSF13C), ELISA Kit

★Popular Item★
 Also Known As   

Human CD268 ELISA Kit

 Product Synonym Names    BAFFR; BR3; Tumor necrosis factor receptor superfamily member 13C; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD268
 Product Gene Name   

TNFRSF13C elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 613494
 3D Structure    ModBase 3D Structure for Q96RJ3
Section Bar
 Species Reactivity    Human
Section Bar
 Specificity    The Human CD268 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human CD268 proteins within the range of 78 pg/ml - 5000 pg/ml.
Section Bar
 Samples    Serum, plasma
 Sensitivity    Typically less than 10 pg/ml.
Section Bar
 Preparation and Storage    Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TNFRSF13C elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TNFRSF13C purchase    MBS824623 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CD268 (TNFRSF13C) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TNFRSF13C, with an estimated sensitivity of Typically less than 10 pg/ml. The ELISA analytical biochemical technique of the MBS824623 kit is based on TNFRSF13C antibody-TNFRSF13C antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TNFRSF13C antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TNFRSF13C. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Table BarTOPTable Bar
 

Related Product Information for TNFRSF13C elisa kit

   Principle of the Assay: The Human CD268 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Human CD268 in Cell Culture Supernatants, Serum, Plasma. This assay employs an antibody specific for Human CD268 coated on a 96-well plate. Standards and samples are pipetted into the wells and CD268 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Human CD268 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of CD268 bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm.

Background/Introduction: Tumor necrosis factor receptor superfamily member 13C also known as B-cell-activating factor receptor or BAFF receptor is a protein that in humans is encoded by the TNFRSF13C gene. By homology to a BAC clone, the BAFFR gene was mapped to chromosome 22q13.1-q13.31. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular phenylalanine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
 Applications Tested/Suitable for TNFRSF13C elisa kit   

Sandwich ELISA (SE)

Section Bar
 Typical Standard Curve/Testing Data of TNFRSF13C elisa kit    TNFRSF13C elisa kit Typical Standard Curve/Testing Data image
Table BarTOPTable Bar
Sample Manual Insert of MBS824623. Click to request current manual
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TNFRSF13C. It may not necessarily be applicable to this product.
 NCBI GI #    16445027
 NCBI GeneID    115650
 NCBI Accession #    NP_443177.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_052945.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q96RJ3 [Other Products]
 UniProt Related Accession #    Q96RJ3 [Other Products]
 Molecular Weight    18,935 Da
Table BarTOPTable Bar
 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 13C
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 13C
 NCBI Official Symbol    TNFRSF13C [Similar Products]
 NCBI Official Synonym Symbols   
BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 13C; BAFF receptor; BLyS receptor 3; B cell-activating factor receptor; B-cell-activating factor receptor
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 13C
 UniProt Synonym Protein Names   
B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD_antigen: CD268
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF13C [Similar Products]
 UniProt Synonym Gene Names    BAFFR; BR3; BAFF-R [Similar Products]
 UniProt Entry Name    TR13C_HUMAN
Section Bar
 NCBI Summary for TNFRSF13C    B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for TNFRSF13C    BAFF-R: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Cell cycle regulation; Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 22q13.1-q13.31

Cellular Component: integral to membrane; external side of plasma membrane

Biological Process: B cell costimulation; B cell homeostasis; T cell costimulation; positive regulation of B cell proliferation; positive regulation of germinal center formation; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 4
Table BarTOPTable Bar
 Research Articles on TNFRSF13C    1. BAFF-R, but not BAFF, may have a role in progression-free survival and overall survival in follicular lymphoma
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with TNFRSF13C elisa kitPathways associated with TNFRSF13C elisa kit
 Reference Product  PubMed Publications
 TNFSF13B elisa kit  >120 publications with TNFRSF13C and TNFSF13B
 TNFRSF13B elisa kit  >54 publications with TNFRSF13C and TNFRSF13B
 TRAF3 elisa kit  >8 publications with TNFRSF13C and TRAF3
 PTPRC elisa kit  >1 publications with TNFRSF13C and PTPRC
 CXCR5 elisa kit  >1 publications with TNFRSF13C and CXCR5
 POU2AF1 elisa kit  >1 publications with TNFRSF13C and POU2AF1
 TRAF1 elisa kit  >1 publications with TNFRSF13C and TRAF1
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
Diseases associated with TNFRSF13C elisa kitOrgans/Tissues associated with TNFRSF13C elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >139 publications with TNFRSF13C and Necrosis
 Inflammation Antibodies  >21 publications with TNFRSF13C and Inflammation
 Common Variable Immunodeficiency Antibodies  >10 publications with TNFRSF13C and Common Variable Immunodeficiency
 Kidney Diseases Antibodies  >7 publications with TNFRSF13C and Kidney Diseases
 Hyperplasia Antibodies  >6 publications with TNFRSF13C and Hyperplasia
 Atherosclerosis Antibodies  >4 publications with TNFRSF13C and Atherosclerosis
 Skin Diseases Antibodies  >4 publications with TNFRSF13C and Skin Diseases
 Demyelinating Diseases Antibodies  >4 publications with TNFRSF13C and Demyelinating Diseases
 Liver Diseases Antibodies  >3 publications with TNFRSF13C and Liver Diseases
 Neoplasms, Experimental Antibodies  >3 publications with TNFRSF13C and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >14 publications with TNFRSF13C and Lymph Node
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions