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CD59 elisa kit :: Human CD59 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2504754
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


★Popular Item★
 Also Known As   

Human CD59 (Protectin) ELISA Kit

 Product Gene Name   

CD59 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    107271
 3D Structure    ModBase 3D Structure for P13987
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human CD59. No significant cross-reactivity or interference between Human CD59 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Human CD59 and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    31.25-2000pg/mL
 Sensitivity    Min: 18.75pg/mL; Max: 2000pg/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CD59 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CD59 purchase    MBS2504754 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CD59, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.25-2000pg/mL in biological research samples containing CD59, with an estimated sensitivity of Min: 18.75pg/mL; Max: 2000pg/mL. The ELISA analytical biochemical technique of the MBS2504754 kit is based on CD59 antibody-CD59 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CD59 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CD59. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for CD59 elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of CD59 in human serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human CD59. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Human CD59 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human CD59, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human CD59. You can calculate the concentration of Human CD59 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of CD59 elisa kit    CD59 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2504754. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CD59. It may not necessarily be applicable to this product.
 NCBI GI #    42716299
 NCBI GeneID    966
 NCBI Accession #    NP_976076.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_203331.2 [Other Products]
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 UniProt Primary Accession #    P13987 [Other Products]
 UniProt Related Accession #    P13987 [Other Products]
 Molecular Weight    14,177 Da
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 NCBI Official Full Name    CD59 glycoprotein preproprotein
 NCBI Official Synonym Full Names    CD59 molecule, complement regulatory protein
 NCBI Official Symbol    CD59 [Similar Products]
 NCBI Official Synonym Symbols   
1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20
[Similar Products]
 NCBI Protein Information    CD59 glycoprotein; 1F5 antigen; 20 kDa homologous restriction factor; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); Ly-6-like protein; MEM43 antigen; T cell-activating protein; human leukocyte antigen MIC11; lymphocytic antigen CD59/MEM43; membrane attack complex (MAC) inhibition factor; membrane attack complex inhibition factor; membrane inhibitor of reactive lysis; protectin; surface anitgen recognized by monoclonal antibody 16.3A5
 UniProt Protein Name    CD59 glycoprotein
 UniProt Synonym Protein Names   
1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD_antigen: CD59
 Protein Family    CD59 glycoprotein
 UniProt Gene Name    CD59 [Similar Products]
 UniProt Synonym Gene Names    MIC11; MIN1; MIN2; MIN3; MSK21; HRF-20; HRF20; MAC-IP; MACIF; MIRL [Similar Products]
 UniProt Entry Name    CD59_HUMAN
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 NCBI Summary for CD59    This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CD59    CD59: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: anchored to external side of plasma membrane; extracellular space; compact myelin; cell surface; focal adhesion; membrane; plasma membrane; extracellular region; vesicle; sarcolemma

Molecular Function: complement binding; protein binding

Biological Process: cell activation; cell surface receptor linked signal transduction; regulation of complement activation; negative regulation of activation of membrane attack complex; innate immune response; positive regulation of T cell proliferation; blood coagulation; negative regulation of apoptosis

Disease: Hemolytic Anemia, Cd59-mediated, With Or Without Immune-mediated Polyneuropathy
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 Research Articles on CD59    1. The presence of CD55- and/or CD59-deficient erythrocytic populations in patients with rheumatic diseases reflects an immune-mediated bone-marrow derived phenomenon.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CD59 elisa kitPathways associated with CD59 elisa kit
 Reference Product  PubMed Publications
 CD55 elisa kit  >820 publications with CD59 and CD55
 CD46 elisa kit  >315 publications with CD59 and CD46
 PIGA elisa kit  >24 publications with CD59 and PIGA
 CAV1 elisa kit  >5 publications with CD59 and CAV1
 C8A elisa kit  >1 publications with CD59 and C8A
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram
Diseases associated with CD59 elisa kitOrgans/Tissues associated with CD59 elisa kit
 Disease Name  Pubmed Publications
 Anemia Antibodies  >406 publications with CD59 and Anemia
 Hemolysis Antibodies  >188 publications with CD59 and Hemolysis
 Inflammation Antibodies  >151 publications with CD59 and Inflammation
 Disease Models, Animal Antibodies  >75 publications with CD59 and Disease Models, Animal
 Lymphoma Antibodies  >67 publications with CD59 and Lymphoma
 Kidney Diseases Antibodies  >52 publications with CD59 and Kidney Diseases
 Adenocarcinoma Antibodies  >37 publications with CD59 and Adenocarcinoma
 Brain Diseases Antibodies  >34 publications with CD59 and Brain Diseases
 Breast Neoplasms Antibodies  >27 publications with CD59 and Breast Neoplasms
 CD59 Deficiency Antibodies  >27 publications with CD59 and CD59 Deficiency
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >943 publications with CD59 and Blood
 Vascular Antibodies  >203 publications with CD59 and Vascular
 Bone Antibodies  >189 publications with CD59 and Bone
 Bone Marrow Antibodies  >181 publications with CD59 and Bone Marrow
 Kidney Antibodies  >118 publications with CD59 and Kidney
 Heart Antibodies  >91 publications with CD59 and Heart
 Liver Antibodies  >75 publications with CD59 and Liver
 Muscle Antibodies  >74 publications with CD59 and Muscle
 Lung Antibodies  >67 publications with CD59 and Lung
 Brain Antibodies  >61 publications with CD59 and Brain
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