NP_001251.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,156 Da
NCBI Official Full Name
cyclin-dependent kinase 8
NCBI Official Synonym Full Names
cyclin-dependent kinase 8
NCBI Official Synonym Symbols
NCBI Protein Information
cyclin-dependent kinase 8; CDK8 protein kinase; cell division protein kinase 8; mediator complex subunit CDK8; mediator of RNA polymerase II transcription subunit CDK8; protein kinase K35
UniProt Protein Name
Cyclin-dependent kinase 8
UniProt Synonym Protein Names
Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35
UniProt Entry Name
CDK8_HUMAN
NCBI Summary for CDK8
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]
UniProt Comments for CDK8
CDK8: a protein kinase of the CDK family. Along with cyclin C forms part of the RNA polymerase II holoenzyme complex. Phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. Regulates transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
Protein type: EC 2.7.11.23; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.22; Protein kinase, CMGC; Cell cycle regulation; CMGC group; CDK family; CDK8 subfamily
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: nucleoplasm; Srb-mediator complex; nucleus
Molecular Function: RNA polymerase subunit kinase activity; protein binding; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity
Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; transcription, DNA-dependent; regulation of cell cycle; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation
Research Articles on CDK8
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Products associated with CDK8 elisa kit
Pathways associated with CDK8 elisa kit
Diseases associated with CDK8 elisa kit
Organs/Tissues associated with CDK8 elisa kit
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