NP_008949.4
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
268,241 Da
NCBI Official Full Name
centriolin
NCBI Official Synonym Full Names
centriolin
NCBI Protein Information
centriolin; 110 kDa centrosomal protein; bA165P4.1 (ortholog of mouse Ma2a8); bA165P4.2 (centrosomal protein 1); centriole associated protein; centrosomal protein 110kDa; centrosomal protein of 110 kDa
UniProt Protein Name
Centriolin
UniProt Synonym Protein Names
Centrosomal protein 1; Centrosomal protein of 110 kDa; Cep110
UniProt Synonym Gene Names
UniProt Entry Name
CNTRL_HUMAN
NCBI Summary for CEP110
This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centrosomal protein 1. [provided by RefSeq, Jul 2008]
UniProt Comments for CEP110
centriolin: Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle- mediated abscission. A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Microtubule-binding
Chromosomal Location of Human Ortholog: 9q33.2
Cellular Component: centrosome; membrane; cytoplasm; cytosol
Molecular Function: protein binding
Biological Process: cell division; organelle organization and biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle
Research Articles on CEP110
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with CEP110 elisa kit
Diseases associated with CEP110 elisa kit
Organs/Tissues associated with CEP110 elisa kit
|