AAF91089.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,932 Da
NCBI Official Full Name
cardiac myosin light chain-1
NCBI Official Synonym Full Names
myosin, light chain 3, alkali; ventricular, skeletal, slow
NCBI Protein Information
myosin light chain 3; CMLC1; cardiac myosin light chain 1; myosin light chain 1, slow-twitch muscle B/ventricular isoform; myosin, light polypeptide 3, alkali; ventricular, skeletal, slow; ventricular/slow twitch myosin alkali light chain
UniProt Protein Name
Myosin light chain 3
UniProt Synonym Protein Names
Cardiac myosin light chain 1; CMLC1; Myosin light chain 1, slow-twitch muscle B/ventricular isoform; MLC1SB; Ventricular/slow twitch myosin alkali light chain
UniProt Synonym Gene Names
UniProt Entry Name
MYL3_HUMAN
NCBI Summary for CMLC-1
MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Comments for CMLC-1
MYL3: Regulatory light chain of myosin. Does not bind calcium. Defects in MYL3 are the cause of familial hypertrophic cardiomyopathy type 8 (CMH8). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.
Protein type: Motor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p21.3-p21.2
Cellular Component: I band; sarcomere; muscle myosin complex; cytosol; A band
Molecular Function: actin monomer binding; structural constituent of muscle; motor activity; myosin II heavy chain binding; calcium ion binding
Biological Process: skeletal muscle development; metabolic process; positive regulation of ATPase activity; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; regulation of the force of heart contraction; muscle filament sliding; cardiac muscle contraction
Disease: Cardiomyopathy, Familial Hypertrophic, 8
Research Articles on CMLC-1
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Products associated with CMLC-1 elisa kit
Pathways associated with CMLC-1 elisa kit
Diseases associated with CMLC-1 elisa kit
Organs/Tissues associated with CMLC-1 elisa kit
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