CAA43850.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
40,413 Da
NCBI Official Full Name
Cx40
NCBI Official Synonym Full Names
gap junction protein, alpha 5
NCBI Official Synonym Symbols
Cx40; Cnx40; Gja-5; 5730555N10Rik [Similar Products]
NCBI Protein Information
gap junction alpha-5 protein; connexin-40; gap junction membrane channel protein alpha 5
UniProt Protein Name
Gap junction alpha-5 protein
UniProt Synonym Protein Names
Connexin-40; Cx40
UniProt Synonym Gene Names
UniProt Entry Name
CXA5_MOUSE
UniProt Comments for CX40
GJA5: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJA5 are a cause of familial atrial standstill (FAS). Atrial standstill is an extremely rare arrhythmia, characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. Defects in GJA5 are the cause of familial atrial fibrillation type 11 (ATFB11). ATFB11 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the connexin family. Alpha-type (group II) subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, misc.; Motility/polarity/chemotaxis
Cellular Component: connexon complex; cell projection; membrane; integral to plasma membrane; integral to membrane; gap junction; plasma membrane; cell junction
Molecular Function: gap junction hemi-channel activity; gap junction channel activity
Biological Process: blood vessel development; gap junction assembly; negative regulation of glomerular filtration; regulation of vasodilation; positive regulation of vasodilation; protein oligomerization; regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by renal system process; embryonic heart tube development; artery morphogenesis; cell communication; negative regulation of blood pressure; skeletal development; potassium ion transport; embryonic limb morphogenesis
Research Articles on CX40
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Pathways associated with CX40 elisa kit
Diseases associated with CX40 elisa kit
Organs/Tissues associated with CX40 elisa kit
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