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CXCL13 elisa kit :: Human CXCL13/BLC ELISA Kit

Scan QR to view Datasheet Catalog #    MBS176488
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
96-Strip-Wells  /  $390 +1 FREE 8GB USB
 
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 Product Name   

CXCL13/BLC, ELISA Kit

★Popular Item★
 Also Known As   

Human CXCL13/BLC PicoKine ELISA Kit

 Product Synonym Names    C-X-C motif chemokine 13; chemokine (C-X-C motif) ligand 13; ANGIE; ANGIE2; B cell attracting chemokine 1; B cell chemoattractant; B cell homing chemokine (ligand for Burkitt's lymphoma receptor 1); B lymphocyte chemoattractant; BCA 1; BLC; BLR1L; C X C motif chemokine 13; Chemokine (C X C motif) ligand 13; Chemokine (C X C motif) ligand 13 (B cell chemoattractant); Chemokine CXC motif ligand 13; CXC chemokine BLC; CXCL13; SCYB13; Small inducible cytokine B subfamily (Cys X Cys motif) member 13 (B cell chemoattractant); Small inducible cytokine B13; Small inducible cytokine subfamily B, member 13
 Product Gene Name   

CXCL13 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    605149
 3D Structure    ModBase 3D Structure for O43927
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 Species Reactivity    Human
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 Specificity    Natural and recombinant human CXCL13
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 Samples    Cell culture supernates, serum, plasma (heparin, EDTA) and saliva
 Assay Type    Sandwich
 Detection Range    15.6pg/ml-1000pg/ml
 Sensitivity    < 1pg/ml
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 Preparation and Storage    Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CXCL13 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CXCL13 purchase    MBS176488 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CXCL13/BLC, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.6pg/ml-1000pg/ml in biological research samples containing CXCL13, with an estimated sensitivity of < 1pg/ml. The ELISA analytical biochemical technique of the MBS176488 kit is based on CXCL13 antibody-CXCL13 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CXCL13 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CXCL13. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Cell culture supernates, serum, plasma (heparin, EDTA) and saliva. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for CXCL13 elisa kit

   Principle of the assay: human CXCL13 ELISA Kit is based on standard sandwich enzyme-linked immune-sorbent assay technology. A monoclonal antibody from mouse specific for CXCL13 has been precoated onto 96-well plates. Standards (E.coli,V23-R94) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for CXCL13 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex is added and unbound conjugates are washed away with PBS or TBS buffer. HRP substrate TMB are used to visualize HRP enzymatic reaction. TMB is catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the human CXCL13 amount of sample captured in plate.
Background: C-X-C motif chemokine 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC), is a protein that in humans is encoded by theCXCL13 gene. CXCL13 is a small cytokine belonging to the CXC chemokine family, and it was located on sequence maps to 4q21, near the genes encoding most CXC chemokines. In T-lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T-cell. Hence, expression of CXCL13 in T-cell lymphomas, such as Angioimmunoblastic T-cell Lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells
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 Typical Testing Data/Standard Curve (for reference only) of CXCL13 elisa kit    Human CXCL13/BLC PicoKine ELISA Kit standard curve
CXCL13 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS176488. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CXCL13. It may not necessarily be applicable to this product.
 NCBI GI #    7673945
 NCBI GeneID    10563
 NCBI Accession #    O43927.1 [Other Products]
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 UniProt Primary Accession #    O43927 [Other Products]
 UniProt Related Accession #    O43927 [Other Products]
 Molecular Weight    12,664 Da
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 NCBI Official Full Name    C-X-C motif chemokine 13
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 13
 NCBI Official Symbol    CXCL13 [Similar Products]
 NCBI Official Synonym Symbols   
BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 13; CXC chemokine BLC; B-cell chemoattractant; B-lymphocyte chemoattractant; b lymphocyte chemoattractant; small-inducible cytokine B13; B-cell-attracting chemokine 1; b cell-attracting chemokine 1; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)
 UniProt Protein Name    C-X-C motif chemokine 13
 UniProt Synonym Protein Names   
Angie; B cell-attracting chemokine 1; BCA-1; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13
 Protein Family    C-X-C motif chemokine
 UniProt Gene Name    CXCL13 [Similar Products]
 UniProt Synonym Gene Names    BCA1; BLC; SCYB13; BCA-1 [Similar Products]
 UniProt Entry Name    CXL13_HUMAN
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 NCBI Summary for CXCL13    B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]
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 UniProt Comments for CXCL13    CXCL13: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; CXCR3 chemokine receptor binding; fibroblast growth factor binding; chemokine activity; protein heterodimerization activity; CXCR5 chemokine receptor binding; CCR10 chemokine receptor binding; receptor agonist activity

Biological Process: chronic inflammatory response; lymphocyte chemotaxis across high endothelial venule; response to lipopolysaccharide; lymph node development; positive regulation of integrin activation; regulation of angiogenesis; positive regulation of cell-cell adhesion mediated by integrin; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; regulation of humoral immune response; defense response to bacterium; germinal center formation; immune response; inflammatory response
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 Research Articles on CXCL13    1. CXCL13 displays antimicrobial activity against E. coli and S. aureus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CXCL13 elisa kitPathways associated with CXCL13 elisa kit
 Reference Product  PubMed Publications
 CXCR5 elisa kit  >184 publications with CXCL13 and CXCR5
 CCL21 elisa kit  >121 publications with CXCL13 and CCL21
 CCL19 elisa kit  >97 publications with CXCL13 and CCL19
 CCR7 elisa kit  >50 publications with CXCL13 and CCR7
 CXCL9 elisa kit  >28 publications with CXCL13 and CXCL9
 CXCR3 elisa kit  >27 publications with CXCL13 and CXCR3
 CCL20 elisa kit  >23 publications with CXCL13 and CCL20
 CXCL11 elisa kit  >14 publications with CXCL13 and CXCL11
 CCL25 elisa kit  >12 publications with CXCL13 and CCL25
 CXCR1 elisa kit  >8 publications with CXCL13 and CXCR1
 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with CXCL13 elisa kitOrgans/Tissues associated with CXCL13 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >148 publications with CXCL13 and Inflammation
 Necrosis Antibodies  >57 publications with CXCL13 and Necrosis
 Disease Models, Animal Antibodies  >47 publications with CXCL13 and Disease Models, Animal
 Carcinoma Antibodies  >30 publications with CXCL13 and Carcinoma
 Lung Diseases Antibodies  >29 publications with CXCL13 and Lung Diseases
 Neoplasms, Experimental Antibodies  >18 publications with CXCL13 and Neoplasms, Experimental
 Hyperplasia Antibodies  >18 publications with CXCL13 and Hyperplasia
 Adenocarcinoma Antibodies  >12 publications with CXCL13 and Adenocarcinoma
 Liver Diseases Antibodies  >12 publications with CXCL13 and Liver Diseases
 Skin Neoplasms Antibodies  >10 publications with CXCL13 and Skin Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >178 publications with CXCL13 and Lymph Node
 Spleen Antibodies  >78 publications with CXCL13 and Spleen
 Bone Antibodies  >67 publications with CXCL13 and Bone
 Vascular Antibodies  >65 publications with CXCL13 and Vascular
 Lung Antibodies  >43 publications with CXCL13 and Lung
 Kidney Antibodies  >23 publications with CXCL13 and Kidney
 Pharynx Antibodies  >20 publications with CXCL13 and Pharynx
 Intestine Antibodies  >19 publications with CXCL13 and Intestine
 Muscle Antibodies  >19 publications with CXCL13 and Muscle
 Prostate Antibodies  >18 publications with CXCL13 and Prostate
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