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CXCR2 elisa kit :: Human CXCR2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2516149
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CXCR2, ELISA Kit

★Popular Item★
 Also Known As   

Human CXCR2(CXC-Chemokine Receptor 2) ELISA Kit

 Product Gene Name   

CXCR2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    146928
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinantHumanCXCR2. No significant cross-reactivity or interference between HumanCXCR2 and analogues was observed.
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 Samples    Serum, plasma and other biological fluids.
 Assay Type    Sandwich (Quantitative)
 Detection Range    0.781-50ng/mL
 Sensitivity    0.469ng/mL
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 Preparation and Storage    Store at 4 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CXCR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CXCR2 purchase    MBS2516149 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CXCR2, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.781-50ng/mL in biological research samples containing CXCR2, with an estimated sensitivity of 0.469ng/mL. The ELISA analytical biochemical technique of the MBS2516149 kit is based on CXCR2 antibody-CXCR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CXCR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CXCR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for CXCR2 elisa kit

   Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanCXCR2concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to CXCR2. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for CXCR2and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain CXCR2, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of CXCR2.You can calculate the concentration of CXCR2in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of CXCR2 elisa kit    CXCR2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2516149. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CXCR2. It may not necessarily be applicable to this product.
 NCBI GI #    269973859
 NCBI GeneID    3579
 NCBI Accession #    NP_001161770.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001168298.1 [Other Products]
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 UniProt Secondary Accession #    Q8IUZ1; Q9P2T6; Q9P2T7 [Other Products]
 UniProt Related Accession #    P25025; AAA15417; AAB24742 [Other Products]
 Molecular Weight    40,759 Da
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 NCBI Official Full Name    C-X-C chemokine receptor type 2
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) receptor 2
 NCBI Official Symbol    CXCR2 [Similar Products]
 NCBI Official Synonym Symbols   
CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b
[Similar Products]
 NCBI Protein Information    C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; IL-8 receptor type 2; IL-8R B; chemokine (CXC) receptor 2; high affinity interleukin-8 receptor B; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B
 UniProt Protein Name    C-X-C chemokine receptor type 2
 UniProt Synonym Protein Names   
CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD_antigen: CD182
 Protein Family    C-X-C chemokine receptor
 UniProt Gene Name    CXCR2 [Similar Products]
 UniProt Synonym Gene Names    IL8RB; CXC-R2; CXCR-2; IL-8R B [Similar Products]
 UniProt Entry Name    CXCR2_HUMAN
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 NCBI Summary for CXCR2    The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
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 UniProt Comments for CXCR2    IL-8R B: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, cytokine; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cell surface; mast cell granule; membrane; integral to plasma membrane; plasma membrane; intracellular

Molecular Function: signal transducer activity; protein binding; interleukin-8 receptor activity; interleukin-8 binding; C-X-C chemokine receptor activity

Biological Process: neutrophil chemotaxis; neutrophil activation; signal transduction; chemotaxis; positive regulation of vascular permeability; negative regulation of neutrophil apoptosis; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; cell surface receptor linked signal transduction; receptor internalization; positive regulation of cell proliferation; midbrain development; dendritic cell chemotaxis; cellular defense response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); inflammatory response; acute inflammatory response to antigenic stimulus
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 Research Articles on CXCR2    1. CXCR2 ubiquitination on K327 residue modulates agonist-activated CXCR2 cell sorting and intracellular signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CXCR2 elisa kitPathways associated with CXCR2 elisa kit
 Reference Product  PubMed Publications
 CXCR1 elisa kit  >505 publications with CXCR2 and CXCR1
 CXCL1 elisa kit  >327 publications with CXCR2 and CXCL1
 CXCL2 elisa kit  >151 publications with CXCR2 and CXCL2
 CXCL5 elisa kit  >87 publications with CXCR2 and CXCL5
 IL8 elisa kit  >75 publications with CXCR2 and IL8
 CXCL6 elisa kit  >24 publications with CXCR2 and CXCL6
 CXCL3 elisa kit  >12 publications with CXCR2 and CXCL3
 PPBP elisa kit  >11 publications with CXCR2 and PPBP
 VASP elisa kit  >1 publications with CXCR2 and VASP
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with CXCR2 elisa kitOrgans/Tissues associated with CXCR2 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >502 publications with CXCR2 and Inflammation
 Lung Diseases Antibodies  >186 publications with CXCR2 and Lung Diseases
 Disease Models, Animal Antibodies  >162 publications with CXCR2 and Disease Models, Animal
 Necrosis Antibodies  >127 publications with CXCR2 and Necrosis
 Sepsis Antibodies  >61 publications with CXCR2 and Sepsis
 Asthma Antibodies  >48 publications with CXCR2 and Asthma
 Liver Diseases Antibodies  >41 publications with CXCR2 and Liver Diseases
 Adenocarcinoma Antibodies  >38 publications with CXCR2 and Adenocarcinoma
 Fibrosis Antibodies  >37 publications with CXCR2 and Fibrosis
 Neoplasms, Experimental Antibodies  >35 publications with CXCR2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >765 publications with CXCR2 and Blood
 Lung Antibodies  >239 publications with CXCR2 and Lung
 Bone Antibodies  >130 publications with CXCR2 and Bone
 Brain Antibodies  >94 publications with CXCR2 and Brain
 Intestine Antibodies  >42 publications with CXCR2 and Intestine
 Heart Antibodies  >38 publications with CXCR2 and Heart
 Spleen Antibodies  >31 publications with CXCR2 and Spleen
 Prostate Antibodies  >26 publications with CXCR2 and Prostate
 Connective Tissue Antibodies  >24 publications with CXCR2 and Connective Tissue
 Trachea Antibodies  >6 publications with CXCR2 and Trachea
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