NP_004925.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,677 Da
NCBI Official Full Name
cadherin-18 isoform 1 preproprotein
NCBI Official Synonym Full Names
cadherin 18, type 2
NCBI Protein Information
cadherin-18; cadherin-14; ey-cadherin; cadherin-like 24
UniProt Protein Name
Cadherin-18
UniProt Synonym Protein Names
Cadherin-14
UniProt Synonym Gene Names
UniProt Entry Name
CAD18_HUMAN
NCBI Summary for CDH18
This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
UniProt Comments for CDH18
CDH18: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5p14.3
Cellular Component: integral to membrane; plasma membrane
Molecular Function: calcium ion binding
Biological Process: intercellular junction assembly and maintenance; homophilic cell adhesion
Research Articles on CDH18
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Products associated with CDH18 elisa kit
Pathways associated with CDH18 elisa kit
Diseases associated with CDH18 elisa kit
Organs/Tissues associated with CDH18 elisa kit
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