NP_569735.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,997 Da
NCBI Official Full Name
carbohydrate sulfotransferase 14
NCBI Official Synonym Full Names
carbohydrate sulfotransferase 14
NCBI Protein Information
carbohydrate sulfotransferase 14
UniProt Protein Name
Carbohydrate sulfotransferase 14
UniProt Synonym Protein Names
Dermatan 4-sulfotransferase 1; D4ST-1; hD4ST1
UniProt Synonym Gene Names
NCBI Summary for CHST14
This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]
UniProt Comments for CHST14
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development.
Research Articles on CHST14
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Products associated with CHST14 elisa kit
Pathways associated with CHST14 elisa kit
Diseases associated with CHST14 elisa kit
Organs/Tissues associated with CHST14 elisa kit
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