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CPB2 elisa kit :: Human Carboxypeptidase B2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2886611
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $380 +1 FREE 8GB USB
96-Strip-Wells  /  $500 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,170 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,840 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Carboxypeptidase B2 (CPB2), ELISA Kit

★Popular Item★
 Also Known As   

Human Carboxypeptidase B2 ELISA Kit

 Product Synonym Names    Carboxypeptidase B2; Carboxypeptidase U; CPU; Plasma carboxypeptidase B; pCPB; Thrombin-activable fibrinolysis inhibitor; TAFI; CPB2; 3.4.17.20
 Product Gene Name   

CPB2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    603101
 3D Structure    ModBase 3D Structure for Q96IY4
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 Species Reactivity    Human
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 Specificity    This assay recognizes recombinant and natural human Carboxypeptidase B2. No significant cross-reactivity or interference was observed.
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 Assay Type    Sandwich
 Detection Range    3.12-200 ng/mL
 Sensitivity    1.7 ng/mL
 Intra-Assay CV    <=6.5%
 Inter-Assay CV    <=9.1%
 Recovery    110%
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 Preparation and Storage    For long term storage, please store the entire kit at -20 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CPB2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CPB2 purchase    MBS2886611 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Carboxypeptidase B2 (CPB2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 3.12-200 ng/mL in biological research samples containing CPB2, with an estimated sensitivity of 1.7 ng/mL. The ELISA analytical biochemical technique of the MBS2886611 kit is based on CPB2 antibody-CPB2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CPB2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CPB2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for CPB2 elisa kit

   Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of human Carboxypeptidase B2 concentrations in serum, Plasma, Urine, tissue homogenates and Cell culture supernates and Other biological fluids.

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to Carboxypeptidase B2. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated polyclonal antibody preparation specific for Carboxypeptidase B2 and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain Carboxypeptidase B2, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of Carboxypeptidase B2 in the samples is then determined by comparing the O.D. of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of CPB2 elisa kit    CPB2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2886611. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CPB2. It may not necessarily be applicable to this product.
 NCBI GI #    513126877
 NCBI GeneID    1361
 NCBI Accession #    NP_001265470.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278541.1 [Other Products]
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 UniProt Primary Accession #    Q96IY4 [Other Products]
 UniProt Secondary Accession #    Q15114; Q5T9K1; Q5T9K2; Q9P2Y6; A8K464 [Other Products]
 UniProt Related Accession #    Q96IY4 [Other Products]
 Molecular Weight    40,922 Da
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 NCBI Official Full Name    carboxypeptidase B2 isoform 2 preproprotein
 NCBI Official Synonym Full Names    carboxypeptidase B2
 NCBI Official Symbol    CPB2 [Similar Products]
 NCBI Official Synonym Symbols   
CPU; PCPB; TAFI
[Similar Products]
 NCBI Protein Information    carboxypeptidase B2
 UniProt Protein Name    Carboxypeptidase B2
 UniProt Synonym Protein Names   
Carboxypeptidase U; CPU; Plasma carboxypeptidase B; pCPB; Thrombin-activable fibrinolysis inhibitor; TAFI
 Protein Family    Carboxypeptidase
 UniProt Gene Name    CPB2 [Similar Products]
 UniProt Synonym Gene Names    CPU; pCPB; TAFI [Similar Products]
 UniProt Entry Name    CBPB2_HUMAN
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 NCBI Summary for CPB2    Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
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 UniProt Comments for CPB2    CPB2: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; EC 3.4.17.20; Protease; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13q14.11

Cellular Component: cell; extracellular space

Molecular Function: metallocarboxypeptidase activity; zinc ion binding

Biological Process: blood coagulation; fibrinolysis; negative regulation of fibrinolysis; proteolysis; response to drug; response to heat
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 Research Articles on CPB2    1. Generated stable deletion mutant of TAFI with full carboxypeptidase activity without activation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CPB2 elisa kitPathways associated with CPB2 elisa kit
 Reference Product  PubMed Publications
 CPE elisa kit  >31 publications with CPB2 and CPE
 PROC elisa kit  >2 publications with CPB2 and PROC
 INS elisa kit  >1 publications with CPB2 and INS
 PLG elisa kit  >1 publications with CPB2 and PLG
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
Diseases associated with CPB2 elisa kitOrgans/Tissues associated with CPB2 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >16 publications with CPB2 and Inflammation
 Necrosis Antibodies  >12 publications with CPB2 and Necrosis
 Cardiovascular Diseases Antibodies  >10 publications with CPB2 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >9 publications with CPB2 and Vascular Diseases
 Liver Diseases Antibodies  >4 publications with CPB2 and Liver Diseases
 Carcinoma Antibodies  >4 publications with CPB2 and Carcinoma
 Edema Antibodies  >3 publications with CPB2 and Edema
 Carcinoma, Hepatocellular Antibodies  >2 publications with CPB2 and Carcinoma, Hepatocellular
 Myocardial Infarction Antibodies  >2 publications with CPB2 and Myocardial Infarction
 Weight Loss Antibodies  >1 publications with CPB2 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >14 publications with CPB2 and Liver
 Muscle Antibodies  >4 publications with CPB2 and Muscle
 Brain Antibodies  >4 publications with CPB2 and Brain
 Embryonic Tissue Antibodies  >1 publications with CPB2 and Embryonic Tissue
 Spleen Antibodies  >1 publications with CPB2 and Spleen
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