NP_001863.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,922 Da
NCBI Official Full Name
carboxypeptidase B2 isoform 1 preproprotein
NCBI Official Synonym Full Names
carboxypeptidase B2
NCBI Protein Information
carboxypeptidase B2
UniProt Protein Name
Carboxypeptidase B2
UniProt Synonym Protein Names
Carboxypeptidase U; CPU; Plasma carboxypeptidase B; pCPB; Thrombin-activable fibrinolysis inhibitor; TAFI
UniProt Synonym Gene Names
UniProt Entry Name
CBPB2_HUMAN
NCBI Summary for CPB2
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Comments for CPB2
CPB2: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; EC 3.4.17.20; Secreted, signal peptide; Protease
Chromosomal Location of Human Ortholog: 13q14.11
Cellular Component: cell; extracellular space
Molecular Function: metallocarboxypeptidase activity; zinc ion binding
Biological Process: blood coagulation; fibrinolysis; negative regulation of fibrinolysis; proteolysis; response to drug; response to heat
Research Articles on CPB2
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Products associated with CPB2 elisa kit
Pathways associated with CPB2 elisa kit
Diseases associated with CPB2 elisa kit
Organs/Tissues associated with CPB2 elisa kit
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