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CAD elisa kit :: Human Caspase Activated DNase (CAD) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS266247 CAD elisa kit
Unit / Price
48-Strip-Wells  /  $275 +1 FREE 8GB USB
96-Strip-Wells  /  $420 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,615 +2 FREE 8GB USB
10x96-Strip-Wells  /  $2,880 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Caspase Activated DNase (CAD), ELISA Kit

 Also Known As   

Human Caspase Activated DNase (CAD) ELISA Kit

 Product Gene Name   

CAD elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    601883
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of CAD elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CAD purchase    MBS266247 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Caspase Activated DNase (CAD) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CAD. The ELISA analytical biochemical technique of the MBS266247 kit is based on CAD antibody-CAD antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CAD antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CAD. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for CAD. It may not necessarily be applicable to this product.
 NCBI GI #    37962942
 NCBI GeneID    1677
 NCBI Accession #    AAR05822.1 [Other Products]
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 UniProt Secondary Accession #    O60521; Q5SR22; Q9BYI4; Q9BYI5; Q9BYI6 [Other Products]
 UniProt Related Accession #    O76075 [Other Products]
 Molecular Weight    11,482 Da
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 NCBI Official Full Name    c-truncated caspase-activated DNase
 NCBI Official Synonym Full Names    DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
 NCBI Official Symbol    DFFB [Similar Products]
 NCBI Official Synonym Symbols   
CAD; CPAN; DFF2; DFF40; DFF-40
[Similar Products]
 NCBI Protein Information    DNA fragmentation factor subunit beta; caspase-activated DNase; caspase-activated nuclease; caspase-activated deoxyribonuclease; DNA fragmentation factor 40 kDa subunit
 UniProt Protein Name    DNA fragmentation factor subunit beta
 UniProt Synonym Protein Names   
Caspase-activated deoxyribonuclease; CAD; Caspase-activated DNase; Caspase-activated nuclease; CPAN; DNA fragmentation factor 40 kDa subunit; DFF-40
 Protein Family    CAD protein
 UniProt Gene Name    DFFB [Similar Products]
 UniProt Synonym Gene Names    CAD; DFF2; DFF40; CAD; Caspase-activated DNase; CPAN; DFF-40 [Similar Products]
 UniProt Entry Name    DFFB_HUMAN
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 NCBI Summary for CAD    Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013]
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 UniProt Comments for CAD    DFFB: Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; EC 3.-.-.-; Deoxyribonuclease

Chromosomal Location of Human Ortholog: 1p36.3

Cellular Component: nucleoplasm; nuclear chromatin; nucleolus; cytosol; nucleus

Molecular Function: enzyme binding; deoxyribonuclease activity

Biological Process: apoptosis; DNA fragmentation during apoptosis; apoptotic chromosome condensation; cell structure disassembly during apoptosis
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 Research Articles on CAD    1. the highest order of chromatin compaction observed in the later steps of caspase-dependent apoptosis relies on DFF40/CAD-mediated DNA damage by generating 3'-OH ends in single-strand rather than double-strand DNA nicks/breaks
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CAD elisa kitPathways associated with CAD elisa kit
 Reference Product  PubMed Publications
 CASP3 elisa kit  >38 publications with CAD and CASP3
 DFFA elisa kit  >5 publications with CAD and DFFA
 DNASE2 elisa kit  >3 publications with CAD and DNASE2
 CIDEA elisa kit  >3 publications with CAD and CIDEA
 CIDEB elisa kit  >2 publications with CAD and CIDEB
 Products by Pathway  Pathway Diagram
 Activation Of DNA Fragmentation Factor Pathway antibodies  Activation Of DNA Fragmentation Factor Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Apoptosis Induced DNA Fragmentation Pathway antibodies  Apoptosis Induced DNA Fragmentation Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
Diseases associated with CAD elisa kitOrgans/Tissues associated with CAD elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >12 publications with CAD and Necrosis
 Carcinoma Antibodies  >7 publications with CAD and Carcinoma
 Neoplasms, Experimental Antibodies  >4 publications with CAD and Neoplasms, Experimental
 Immune System Diseases Antibodies  >4 publications with CAD and Immune System Diseases
 Adenocarcinoma Antibodies  >4 publications with CAD and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >3 publications with CAD and Cardiovascular Diseases
 Cognition Disorders Antibodies  >3 publications with CAD and Cognition Disorders
 Inflammation Antibodies  >2 publications with CAD and Inflammation
 Liver Diseases Antibodies  >2 publications with CAD and Liver Diseases
 Disease Models, Animal Antibodies  >2 publications with CAD and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with CAD and Brain
 Lung Antibodies  >3 publications with CAD and Lung
 Liver Antibodies  >3 publications with CAD and Liver
 Bone Antibodies  >2 publications with CAD and Bone
 Vascular Antibodies  >2 publications with CAD and Vascular
 Connective Tissue Antibodies  >2 publications with CAD and Connective Tissue
 Skin Antibodies  >1 publications with CAD and Skin
 Testis Antibodies  >1 publications with CAD and Testis
 Bone Marrow Antibodies  >1 publications with CAD and Bone Marrow
 Kidney Antibodies  >1 publications with CAD and Kidney
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