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IGF2R elisa kit :: Human Cation-independent mannose-6-phosphate receptor ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2880998
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $380 +1 FREE 8GB USB
96-Strip-Wells  /  $500 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,170 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,840 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cation-independent mannose-6-phosphate receptor (IGF2R), ELISA Kit

★Popular Item★
 Also Known As   

Human Cation-independent mannose-6-phosphate receptor ELISA Kit

 Product Synonym Names    Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like
 Product Gene Name   

IGF2R elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2880998 Testing Data    Testing Data PDF
 OMIM    147280
 3D Structure    ModBase 3D Structure for P11717
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 Species Reactivity    Human
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 Assay Type    Sandwich
 Detection Range    0.312-20 ng/ml
 Sensitivity    0.174 ng/mL
 Intra-Assay CV    <=7.8%
 Inter-Assay CV    <=11.6%
 Recovery    106%
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 Preparation and Storage    For long term storage, please store the entire kit at -20 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IGF2R elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IGF2R purchase    MBS2880998 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cation-independent mannose-6-phosphate receptor (IGF2R) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.312-20 ng/ml in biological research samples containing IGF2R, with an estimated sensitivity of 0.174 ng/mL. The ELISA analytical biochemical technique of the MBS2880998 kit is based on IGF2R antibody-IGF2R antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IGF2R antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IGF2R. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for IGF2R elisa kit

   Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of IGF2R elisa kit    IGF2R elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2880998. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IGF2R. It may not necessarily be applicable to this product.
 NCBI GI #    119964726
 NCBI GeneID    3482
 NCBI Accession #    NP_000867.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000876.3 [Other Products]
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 UniProt Primary Accession #    P11717 [Other Products]
 UniProt Secondary Accession #    Q7Z7G9; Q96PT5 [Other Products]
 UniProt Related Accession #    P11717 [Other Products]
 Molecular Weight    274,375 Da
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 NCBI Official Full Name    cation-independent mannose-6-phosphate receptor
 NCBI Official Synonym Full Names    insulin like growth factor 2 receptor
 NCBI Official Symbol    IGF2R [Similar Products]
 NCBI Official Synonym Symbols   
MPR1; MPRI; CD222; CIMPR; M6P-R; MPR 300; M6P/IGF2R
[Similar Products]
 NCBI Protein Information    cation-independent mannose-6-phosphate receptor
 UniProt Protein Name    Cation-independent mannose-6-phosphate receptor
 UniProt Synonym Protein Names   
300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD_antigen: CD222
 Protein Family    Cation-independent mannose-6-phosphate receptor
 UniProt Gene Name    IGF2R [Similar Products]
 UniProt Synonym Gene Names    MPRI; CI Man-6-P receptor; CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R [Similar Products]
 UniProt Entry Name    MPRI_HUMAN
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 NCBI Summary for IGF2R    This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
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 UniProt Comments for IGF2R    IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family.

Protein type: Membrane protein, integral; Vesicle; Receptor, misc.

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: cell surface; clathrin coat; early endosome; endocytic vesicle; endosome; extracellular space; focal adhesion; integral to plasma membrane; late endosome; lysosomal membrane; membrane; nuclear envelope lumen; perinuclear region of cytoplasm; trans-Golgi network; trans-Golgi network transport vesicle

Molecular Function: enzyme binding; G-protein alpha-subunit binding; G-protein coupled receptor activity; glycoprotein binding; identical protein binding; insulin-like growth factor II binding; insulin-like growth factor receptor activity; mannose binding; phosphoprotein binding; protein binding; receptor activity; retinoic acid binding; transporter activity

Biological Process: G-protein coupled receptor protein signaling pathway; insulin-like growth factor receptor signaling pathway; liver development; organ regeneration; positive regulation of apoptosis; post-embryonic development; receptor-mediated endocytosis; response to retinoic acid; signal transduction; spermatogenesis

Disease: Hepatocellular Carcinoma
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 Research Articles on IGF2R    1. IGF2R gene polymorphism and circulating IGF2R are associated with T2DM
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IGF2R elisa kitPathways associated with IGF2R elisa kit
 Reference Product  PubMed Publications
 M6PR elisa kit  >1872 publications with IGF2R and M6PR
 IGF2 elisa kit  >264 publications with IGF2R and IGF2
 GZMB elisa kit  >14 publications with IGF2R and GZMB
 RAB9A elisa kit  >9 publications with IGF2R and RAB9A
 GGA1 elisa kit  >9 publications with IGF2R and GGA1
 GGA3 elisa kit  >8 publications with IGF2R and GGA3
 PLAUR elisa kit  >6 publications with IGF2R and PLAUR
 PACS1 elisa kit  >5 publications with IGF2R and PACS1
 GGA2 elisa kit  >5 publications with IGF2R and GGA2
 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram
Diseases associated with IGF2R elisa kitOrgans/Tissues associated with IGF2R elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >119 publications with IGF2R and Nervous System Diseases
 Brain Diseases Antibodies  >95 publications with IGF2R and Brain Diseases
 Liver Diseases Antibodies  >85 publications with IGF2R and Liver Diseases
 Liver Neoplasms Antibodies  >78 publications with IGF2R and Liver Neoplasms
 Breast Neoplasms Antibodies  >64 publications with IGF2R and Breast Neoplasms
 Death Antibodies  >57 publications with IGF2R and Death
 Carcinoma, Hepatocellular Antibodies  >54 publications with IGF2R and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >48 publications with IGF2R and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >45 publications with IGF2R and Cardiovascular Diseases
 Kidney Diseases Antibodies  >40 publications with IGF2R and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >300 publications with IGF2R and Liver
 Blood Antibodies  >244 publications with IGF2R and Blood
 Muscle Antibodies  >178 publications with IGF2R and Muscle
 Brain Antibodies  >162 publications with IGF2R and Brain
 Embryonic Tissue Antibodies  >150 publications with IGF2R and Embryonic Tissue
 Kidney Antibodies  >138 publications with IGF2R and Kidney
 Heart Antibodies  >95 publications with IGF2R and Heart
 Placenta Antibodies  >95 publications with IGF2R and Placenta
 Ovary Antibodies  >93 publications with IGF2R and Ovary
 Lung Antibodies  >81 publications with IGF2R and Lung
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