NP_001135817.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,322 Da
NCBI Official Full Name
chemokine-like receptor 1 isoform a
NCBI Official Synonym Full Names
chemokine-like receptor 1
NCBI Protein Information
chemokine-like receptor 1; chemerin receptor; resolvin E1 receptor; chemokine receptor-like 1; G-protein coupled receptor DEZ; G-protein coupled receptor ChemR23; orphan G-protein coupled receptor, Dez
UniProt Protein Name
Chemokine-like receptor 1
UniProt Synonym Protein Names
G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ
UniProt Synonym Gene Names
UniProt Entry Name
CML1_HUMAN
UniProt Comments for CHE
CMKLR1: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12q24.1
Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane
Molecular Function: G-protein coupled receptor activity; protein binding; chemokine receptor activity; receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of interleukin-12 production; inhibition of NF-kappaB transcription factor; positive regulation of fat cell differentiation; regulation of calcium-mediated signaling; immune response; chemotaxis; skeletal development
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Organs/Tissues associated with CHE elisa kit
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