NP_000102.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
84,505 Da
NCBI Official Full Name
chloride anion exchanger
NCBI Official Synonym Full Names
solute carrier family 26 (anion exchanger), member 3
NCBI Official Synonym Symbols
NCBI Protein Information
chloride anion exchanger; down-regulated in adenoma protein; solute carrier family 26, member 3
UniProt Protein Name
Chloride anion exchanger
UniProt Synonym Protein Names
Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3
UniProt Synonym Gene Names
UniProt Entry Name
S26A3_HUMAN
NCBI Summary for SLC26A3
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]
UniProt Comments for SLC26A3
SLC26A3: Chloride/bicarbonate exchanger. Mediates the efficient absorbtion of chloride ions in the colon, participating in fluid homeostasis. Defects in SLC26A3 are the cause of diarrhea type 1 (DIAR1); also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q31
Cellular Component: membrane; brush border membrane; integral to plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: bicarbonate transmembrane transporter activity; protein binding; chloride transmembrane transporter activity; transporter activity; anion:anion antiporter activity; transcription cofactor activity; secondary active sulfate transmembrane transporter activity; transcription factor activity
Biological Process: intracellular pH elevation; regulation of transcription, DNA-dependent; bicarbonate transport; membrane hyperpolarization; ion transport; excretion; transmembrane transport; sperm capacitation; anion transport
Disease: Diarrhea 1, Secretory Chloride, Congenital
Research Articles on SLC26A3
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Products associated with SLC26A3 elisa kit
Pathways associated with SLC26A3 elisa kit
Diseases associated with SLC26A3 elisa kit
Organs/Tissues associated with SLC26A3 elisa kit
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