AAC37590.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,394 Da
NCBI Official Full Name
choline acetyltransferase, partial
NCBI Official Synonym Full Names
choline O-acetyltransferase
NCBI Protein Information
choline O-acetyltransferase; choline acetylase; acetyl CoA:choline O-acetyltransferase
UniProt Protein Name
Choline O-acetyltransferase
UniProt Synonym Gene Names
UniProt Entry Name
CLAT_HUMAN
NCBI Summary for ChAT
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]
UniProt Comments for ChAT
CHAT: an enzyme that catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Four alternative splice variants have been described.
Protein type: Acetyltransferase; Lipid Metabolism - glycerophospholipid; EC 2.3.1.6
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: mitochondrion; cell soma; axon; cytoplasm; cytosol; nucleus
Molecular Function: choline O-acetyltransferase activity
Biological Process: synaptic transmission; rhythmic behavior; rhythmic excitation; muscle development; phospholipid metabolic process; neurotransmitter secretion; glycerophospholipid biosynthetic process; dendrite development; phosphatidylcholine biosynthetic process; neuromuscular synaptic transmission; establishment of synaptic specificity at neuromuscular junction; adult walking behavior; neurotransmitter biosynthetic process
Disease: Myasthenic Syndrome, Congenital, Associated With Episodic Apnea
Research Articles on ChAT
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Products associated with ChAT elisa kit
Pathways associated with ChAT elisa kit
Diseases associated with ChAT elisa kit
Organs/Tissues associated with ChAT elisa kit
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