NP_001137453.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,026 Da
NCBI Official Full Name
chordin-like protein 1 isoform 1
NCBI Official Synonym Full Names
chordin-like 1
NCBI Official Synonym Symbols
CHL; MGC1; MGCN; VOPT; NRLN1; dA141H5.1 [Similar Products]
NCBI Protein Information
chordin-like protein 1
UniProt Protein Name
Chordin-like protein 1
UniProt Synonym Protein Names
Neuralin-1; Neurogenesin-1; Ventroptin
UniProt Synonym Gene Names
UniProt Entry Name
CRDL1_HUMAN
NCBI Summary for CHRDL1
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
UniProt Comments for CHRDL1
CHRDL1: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. Defects in CHRDL1 are the cause of megalocornea type 1, X-linked (MGC1). MGC1 is an eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: Xq23
Cellular Component: extracellular region
Biological Process: BMP signaling pathway; neuron differentiation; ossification; eye development; compound eye development; negative regulation of BMP signaling pathway
Disease: Megalocornea
Research Articles on CHRDL1
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Products associated with CHRDL1 elisa kit
Pathways associated with CHRDL1 elisa kit
Diseases associated with CHRDL1 elisa kit
Organs/Tissues associated with CHRDL1 elisa kit
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