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CHM elisa kit :: Human Choroideremia (CHM) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9301992 CHM elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Choroideremia (CHM), ELISA Kit

★Popular Item★
 Also Known As   

Human Choroideremia (CHM) ELISA Kit

 Product Gene Name   

CHM elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: X; NC_000023.10 (85116185..85302566, complement). Location: Xq21.2
 OMIM    300390
 3D Structure    ModBase 3D Structure for P24386
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    31.2 pg/ml - 1000 pg/ml
 Sensitivity    5.0 pg/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CHM elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CHM purchase    MBS9301992 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Choroideremia (CHM) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.2 pg/ml - 1000 pg/ml in biological research samples containing CHM, with an estimated sensitivity of 5.0 pg/ml. The ELISA analytical biochemical technique of the MBS9301992 kit is based on CHM antibody-CHM antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CHM antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CHM. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for CHM elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of CHM (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9301992. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CHM. It may not necessarily be applicable to this product.
 NCBI GI #    119618965
 NCBI GeneID    1121
 NCBI Accession #    EAW98559.1 [Other Products]
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 UniProt Primary Accession #    P24386 [Other Products]
 UniProt Secondary Accession #    O43732; A1L4D2 [Other Products]
 UniProt Related Accession #    P24386 [Other Products]
 Molecular Weight    73,476 Da
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 NCBI Official Full Name    choroideremia (Rab escort protein 1)
 NCBI Official Synonym Full Names    choroideremia (Rab escort protein 1)
 NCBI Official Symbol    CHM [Similar Products]
 NCBI Official Synonym Symbols   
TCD; GGTA; REP-1; DXS540; HSD-32
[Similar Products]
 NCBI Protein Information    rab proteins geranylgeranyltransferase component A 1; choroideremia protein
 UniProt Protein Name    Rab proteins geranylgeranyltransferase component A 1
 UniProt Synonym Protein Names   
Choroideremia protein; Rab escort protein 1; REP-1; TCD protein
 Protein Family    Rab proteins geranylgeranyltransferase component
 UniProt Gene Name    CHM [Similar Products]
 UniProt Synonym Gene Names    REP1; TCD; REP-1 [Similar Products]
 UniProt Entry Name    RAE1_HUMAN
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 NCBI Summary for CHM    This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
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 UniProt Comments for CHM    CHM: Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. Defects in CHM are the cause of choroideremia (CHM). An X-linked recessive disease characterized by a slowly progressive degeneration of the choroid, photoreceptors, and retinal pigment epithelium. Affected males develop night blindness in their teenage years followed by loss of peripheral vision and complete blindness at middle age. Carrier females are generally asymptomatic but funduscopic examination often shows patchy areas of chorioretinal atrophy. Belongs to the Rab GDI family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase

Chromosomal Location of Human Ortholog: Xq21.2

Cellular Component: Rab-protein geranylgeranyltransferase complex; cytosol

Molecular Function: GTPase activator activity; Rab GTPase binding; Rab-protein geranylgeranyltransferase activity

Biological Process: protein geranylgeranylation; blood vessel development; visual perception; response to stimulus; protein targeting to membrane; positive regulation of GTPase activity

Disease: Choroideremia
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 Research Articles on CHM    1. These findings demonstrate a novel CHM mutation that emphasizes severe posterior pole carrier phenotypes, age-related changes, and early choroideremia disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CHM elisa kitDiseases associated with CHM elisa kit
 Reference Product  PubMed Publications
 RAB3A elisa kit  >5 publications with CHM and RAB3A
 RAB1B elisa kit  >4 publications with CHM and RAB1B
 RAB3D elisa kit  >2 publications with CHM and RAB3D
 RAB1A elisa kit  >2 publications with CHM and RAB1A
 RAB5A elisa kit  >1 publications with CHM and RAB5A
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >190 publications with CHM and Neoplasms
 Choroideremia Antibodies  >107 publications with CHM and Choroideremia
 Carcinoma Antibodies  >40 publications with CHM and Carcinoma
 Death Antibodies  >33 publications with CHM and Death
 Nervous System Diseases Antibodies  >31 publications with CHM and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >30 publications with CHM and Cardiovascular Diseases
 Liver Diseases Antibodies  >23 publications with CHM and Liver Diseases
 Congenital Abnormalities Antibodies  >18 publications with CHM and Congenital Abnormalities
 Liver Neoplasms Antibodies  >17 publications with CHM and Liver Neoplasms
 Immune System Diseases Antibodies  >16 publications with CHM and Immune System Diseases
Organs/Tissues associated with CHM elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >128 publications with CHM and Blood
 Eye Antibodies  >71 publications with CHM and Eye
 Bone Antibodies  >59 publications with CHM and Bone
 Vascular Antibodies  >53 publications with CHM and Vascular
 Placenta Antibodies  >48 publications with CHM and Placenta
 Liver Antibodies  >42 publications with CHM and Liver
 Embryonic Tissue Antibodies  >36 publications with CHM and Embryonic Tissue
 Connective Tissue Antibodies  >33 publications with CHM and Connective Tissue
 Lung Antibodies  >26 publications with CHM and Lung
 Brain Antibodies  >25 publications with CHM and Brain
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