NP_001747.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,141 Da
NCBI Official Full Name
corticosteroid-binding globulin
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
NCBI Official Synonym Symbols
NCBI Protein Information
corticosteroid-binding globulin
UniProt Protein Name
Corticosteroid-binding globulin
UniProt Synonym Protein Names
Serpin A6; Transcortin
UniProt Synonym Gene Names
UniProt Entry Name
CBG_HUMAN
NCBI Summary for CBG
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
UniProt Comments for CBG
SERPINA6: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency). CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue. Belongs to the serpin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase inhibitor activity; steroid binding
Biological Process: glucocorticoid metabolic process; transport
Disease: Corticosteroid-binding Globulin Deficiency
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Products associated with CBG elisa kit
Diseases associated with CBG elisa kit
Organs/Tissues associated with CBG elisa kit
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