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CYP2A6 elisa kit :: Human Cytochrome P450 2A6 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2533380
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytochrome P450 2A6 (CYP2A6), ELISA Kit

★Popular Item★
 Also Known As   

Human CYP2A6 (Cytochrome P450 2A6) ELISA Kit

 Product Gene Name   

CYP2A6 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    122720
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinantHumanCYP2A6. No significant cross-reactivity or interference between HumanCYP2A6 and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    1.563-100ng/mL
 Sensitivity    Min: 0.938ng/mL; Max: 100ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CYP2A6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CYP2A6 purchase    MBS2533380 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cytochrome P450 2A6 (CYP2A6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1.563-100ng/mL in biological research samples containing CYP2A6, with an estimated sensitivity of Min: 0.938ng/mL; Max: 100ng/mL. The ELISA analytical biochemical technique of the MBS2533380 kit is based on CYP2A6 antibody-CYP2A6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CYP2A6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CYP2A6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for CYP2A6 elisa kit

   Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanCYP2A6concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to CYP2A6. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for CYP2A6and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain CYP2A6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of CYP2A6.You can calculate the concentration of CYP2A6in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of CYP2A6 elisa kit    CYP2A6 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2533380. Click to request current manual
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NCBI/Uniprot data below describe general gene information for CYP2A6. It may not necessarily be applicable to this product.
 NCBI GI #    189339233
 NCBI GeneID    1548
 NCBI Accession #    NP_000753.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000762.5 [Other Products]
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 UniProt Secondary Accession #    P00190; P10890; Q16803; Q4VAT9; Q4VAU0; Q4VAU1; Q9H1Z7; Q9UCU0; Q9UK48; A7YAE5; B2R7F6 [Other Products]
 UniProt Related Accession #    P11509 [Other Products]
 Molecular Weight    56,501 Da
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 NCBI Official Full Name    cytochrome P450 2A6
 NCBI Official Synonym Full Names    cytochrome P450 family 2 subfamily A member 6
 NCBI Official Symbol    CYP2A6 [Similar Products]
 NCBI Official Synonym Symbols   
CPA6; CYP2A; CYP2A3; P450PB; CYPIIA6; P450C2A
[Similar Products]
 NCBI Protein Information    cytochrome P450 2A6
 UniProt Protein Name    Cytochrome P450 2A6
 UniProt Synonym Protein Names   
1,4-cineole 2-exo-monooxygenase; CYPIIA6; Coumarin 7-hydroxylase; Cytochrome P450 IIA3; Cytochrome P450(I)
 Protein Family    Cytochrome
 UniProt Gene Name    CYP2A6 [Similar Products]
 UniProt Synonym Gene Names    CYP2A3 [Similar Products]
 UniProt Entry Name    CP2A6_HUMAN
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 NCBI Summary for CYP2A6    This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP2A6    CYP2A6: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4- cineole 2-exo-monooxygenase. Possesses low phenacetin O- deethylation activity. Belongs to the cytochrome P450 family.

Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Secondary Metabolites Metabolism - caffeine; EC 1.14.14.1; Cofactor and Vitamin Metabolism - retinol; Endoplasmic reticulum; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasmic microtubule; endoplasmic reticulum membrane

Molecular Function: arachidonic acid epoxygenase activity; coumarin 7-hydroxylase activity; enzyme binding; heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity

Biological Process: coumarin catabolic process; coumarin metabolic process; drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; steroid metabolic process; xenobiotic metabolic process

Disease: Coumarin Resistance; Lung Cancer; Tobacco Addiction, Susceptibility To
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 Research Articles on CYP2A6    1. We have for the first time demonstrated that the tumor suppressor protein, p53, is a regulator of the CYP2A6 gene.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CYP2A6 elisa kitPathways associated with CYP2A6 elisa kit
 Reference Product  PubMed Publications
 NAT2 elisa kit  >29 publications with CYP2A6 and NAT2
 GSTM1 elisa kit  >25 publications with CYP2A6 and GSTM1
 UGT2B7 elisa kit  >20 publications with CYP2A6 and UGT2B7
 GSTT1 elisa kit  >18 publications with CYP2A6 and GSTT1
 UGT1A1 elisa kit  >14 publications with CYP2A6 and UGT1A1
 UGT1A9 elisa kit  >7 publications with CYP2A6 and UGT1A9
 UGT1A6 elisa kit  >7 publications with CYP2A6 and UGT1A6
 DPYD elisa kit  >4 publications with CYP2A6 and DPYD
 UGT1A4 elisa kit  >3 publications with CYP2A6 and UGT1A4
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 CYP2E1 Reactions Pathway antibodies  CYP2E1 Reactions Pathway Diagram
 Caffeine Metabolism Pathway antibodies  Caffeine Metabolism Pathway Diagram
 Caffeine Metabolism Pathway antibodies  Caffeine Metabolism Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
Diseases associated with CYP2A6 elisa kitOrgans/Tissues associated with CYP2A6 elisa kit
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >85 publications with CYP2A6 and Liver Diseases
 Lung Neoplasms Antibodies  >65 publications with CYP2A6 and Lung Neoplasms
 Tobacco Use Disorder Antibodies  >54 publications with CYP2A6 and Tobacco Use Disorder
 Liver Neoplasms Antibodies  >46 publications with CYP2A6 and Liver Neoplasms
 Adenocarcinoma Antibodies  >38 publications with CYP2A6 and Adenocarcinoma
 Disease Models, Animal Antibodies  >19 publications with CYP2A6 and Disease Models, Animal
 Nervous System Diseases Antibodies  >19 publications with CYP2A6 and Nervous System Diseases
 Colorectal Neoplasms Antibodies  >18 publications with CYP2A6 and Colorectal Neoplasms
 Drug-Related Side Effects and Adverse Reactions Antibodies  >18 publications with CYP2A6 and Drug-Related Side Effects and Adverse Reactions
 Drug-Induced Liver Injury Antibodies  >18 publications with CYP2A6 and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >702 publications with CYP2A6 and Liver
 Mixed Antibodies  >625 publications with CYP2A6 and Mixed
 Lung Antibodies  >182 publications with CYP2A6 and Lung
 Kidney Antibodies  >44 publications with CYP2A6 and Kidney
 Brain Antibodies  >38 publications with CYP2A6 and Brain
 Mammary Gland Antibodies  >1 publications with CYP2A6 and Mammary Gland
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