NP_001712.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
78,011 Da
NCBI Official Full Name
cytoplasmic tyrosine-protein kinase BMX
NCBI Official Synonym Full Names
BMX non-receptor tyrosine kinase
NCBI Protein Information
cytoplasmic tyrosine-protein kinase BMX; NTK38 tyrosine kinase; BTK-like on X chromosome; Etk/Bmx cytosolic tyrosine kinase; epithelial and endothelial tyrosine kinase; bone marrow tyrosine kinase gene in chromosome X protein
UniProt Protein Name
Cytoplasmic tyrosine-protein kinase BMX
UniProt Synonym Protein Names
Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38
UniProt Synonym Gene Names
UniProt Entry Name
BMX_HUMAN
NCBI Summary for BMX
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]
UniProt Comments for BMX
Etk: a tyrosine kinase of the Tec family. Activity is required for IL6-induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.
Protein type: Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Tec family
Chromosomal Location of Human Ortholog: Xp22.2
Cellular Component: extrinsic to internal side of plasma membrane; cytosol
Molecular Function: signal transducer activity; protein binding; metal ion binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: adaptive immune response; apoptosis; protein amino acid autophosphorylation; signal transduction; protein amino acid phosphorylation; T cell receptor signaling pathway; regulation of cell proliferation; B cell receptor signaling pathway; innate immune response; mesoderm development; cell adhesion; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; cell structure disassembly during apoptosis
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Products associated with BMX elisa kit
Pathways associated with BMX elisa kit
Diseases associated with BMX elisa kit
Organs/Tissues associated with BMX elisa kit
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