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DAP6 elisa kit :: Human DAP6 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2509879
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DAP6, ELISA Kit

★Popular Item★
 Also Known As   

Human DAP6 (Death Associated Protein 6) ELISA Kit

 Product Gene Name   

DAP6 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    603186
 3D Structure    ModBase 3D Structure for Q9UER7
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinantHumanDAP6. No significant cross-reactivity or interference between HumanDAP6 and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    62.5-4000pg/mL
 Sensitivity    Min: 37.5pg/mL; Max: 4000pg/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of DAP6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for DAP6 purchase    MBS2509879 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the DAP6, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 62.5-4000pg/mL in biological research samples containing DAP6, with an estimated sensitivity of Min: 37.5pg/mL; Max: 4000pg/mL. The ELISA analytical biochemical technique of the MBS2509879 kit is based on DAP6 antibody-DAP6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DAP6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DAP6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for DAP6 elisa kit

   Intended Uses: This ELISA kit applies to the invitro quantitative determination of HumanDAP6concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to DAP6. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for DAP6and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain DAP6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of DAP6.You can calculate the concentration of DAP6in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of DAP6 elisa kit    DAP6 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2509879. Click to request current manual
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NCBI/Uniprot data below describe general gene information for DAP6. It may not necessarily be applicable to this product.
 NCBI GI #    215422388
 NCBI GeneID    1616
 NCBI Accession #    NP_001135441.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001141969.1 [Other Products]
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 UniProt Primary Accession #    Q9UER7 [Other Products]
 UniProt Secondary Accession #    O14747; O15141; O15208; Q5STK9; Q9BWI3; B4E1I3; F5ANJ6; F5ANJ7; F5H082 [Other Products]
 UniProt Related Accession #    Q9UER7 [Other Products]
 Molecular Weight    75,563 Da
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 NCBI Official Full Name    death domain-associated protein 6 isoform a
 NCBI Official Synonym Full Names    death-domain associated protein
 NCBI Official Symbol    DAXX [Similar Products]
 NCBI Official Synonym Symbols   
DAP6; EAP1; BING2
[Similar Products]
 NCBI Protein Information    death domain-associated protein 6; CENP-C binding protein; ETS1-associated protein 1; Fas-binding protein; death-associated protein 6; fas death domain-associated protein
 UniProt Protein Name    Death domain-associated protein 6
 UniProt Synonym Protein Names   
Daxx; hDaxx; ETS1-associated protein 1; EAP1; Fas death domain-associated protein
 UniProt Gene Name    DAXX [Similar Products]
 UniProt Synonym Gene Names    BING2; DAP6; hDaxx; EAP1 [Similar Products]
 UniProt Entry Name    DAXX_HUMAN
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 NCBI Summary for DAP6    This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
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 UniProt Comments for DAP6    DAXX: a transcriptional co-regulatory protein. Proposed to mediate activation of the JNK pathway and apoptosis via ASK1 in response to signaling from FAS and TGF-betaR2. Glucose deprivation activates the ASK1-SEK1-JNK1-HIPK1 pathway, relocalizing Daxx from the nucleus to the cytoplasm, where Daxx binds to ASK1, and subsequently leads to ASK1 oligomerization. Interaction with HSP27 may prevent interaction with TGF-betaR2 and ASK1 and block DAXX-mediated apoptosis. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Two alternatively spliced isoforms have been described.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Nucleolus; Apoptosis

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: heterochromatin; PML body; cytoplasm; nucleolus; cytosol; nucleus; chromosome, pericentric region

Molecular Function: protein homodimerization activity; histone binding; p53 binding; protein N-terminus binding; transcription factor binding; protein kinase binding; protein binding; enzyme binding; androgen receptor binding; heat shock protein binding; ubiquitin protein ligase binding; receptor signaling protein activity; transcription corepressor activity; protein kinase activator activity

Biological Process: chromatin remodeling; nucleosome assembly; cytokinesis after mitosis; induction of apoptosis via death domain receptors; viral reproduction; transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of protein ubiquitination; apoptosis; positive regulation of protein kinase activity; androgen receptor signaling pathway; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; activation of JNK activity
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 Research Articles on DAP6    1. Authors propose that Epstein-Barr virus tegument protein BNRF1 replaces ATRX to reprogram Daxx-mediated H3.3 loading, in turn generating chromatin suitable for latent gene expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DAP6 elisa kitPathways associated with DAP6 elisa kit
 Reference Product  PubMed Publications
 PML elisa kit  >128 publications with DAP6 and PML
 ATRX elisa kit  >67 publications with DAP6 and ATRX
 SUMO1 elisa kit  >39 publications with DAP6 and SUMO1
 MDM2 elisa kit  >17 publications with DAP6 and MDM2
 MAP3K5 elisa kit  >17 publications with DAP6 and MAP3K5
 TP53 elisa kit  >15 publications with DAP6 and TP53
 ETS1 elisa kit  >9 publications with DAP6 and ETS1
 USP7 elisa kit  >7 publications with DAP6 and USP7
 HIPK2 elisa kit  >7 publications with DAP6 and HIPK2
 UBC elisa kit  >1 publications with DAP6 and UBC
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 HIV-1 Nef: Negative Effector Of Fas And TNF-alpha Pathway antibodies  HIV-1 Nef: Negative Effector Of Fas And TNF-alpha Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
Diseases associated with DAP6 elisa kitOrgans/Tissues associated with DAP6 elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >26 publications with DAP6 and Necrosis
 Neuroendocrine Tumors Antibodies  >25 publications with DAP6 and Neuroendocrine Tumors
 Brain Diseases Antibodies  >19 publications with DAP6 and Brain Diseases
 Pancreatic Neoplasms Antibodies  >18 publications with DAP6 and Pancreatic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >10 publications with DAP6 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >7 publications with DAP6 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >6 publications with DAP6 and Breast Neoplasms
 Inflammation Antibodies  >5 publications with DAP6 and Inflammation
 Kidney Diseases Antibodies  >4 publications with DAP6 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >4 publications with DAP6 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >40 publications with DAP6 and Blood
 Brain Antibodies  >33 publications with DAP6 and Brain
 Prostate Antibodies  >17 publications with DAP6 and Prostate
 Kidney Antibodies  >12 publications with DAP6 and Kidney
 Liver Antibodies  >11 publications with DAP6 and Liver
 Vascular Antibodies  >10 publications with DAP6 and Vascular
 Muscle Antibodies  >9 publications with DAP6 and Muscle
 Bone Antibodies  >8 publications with DAP6 and Bone
 Heart Antibodies  >8 publications with DAP6 and Heart
 Bone Marrow Antibodies  >7 publications with DAP6 and Bone Marrow
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