NP_001277134.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
63,309 Da
NCBI Official Full Name
mRNA-decapping enzyme 1A isoform c
NCBI Official Synonym Full Names
decapping mRNA 1A
NCBI Official Synonym Symbols
SMIF; SMAD4IP1; HSA275986; Nbla00360 [Similar Products]
NCBI Protein Information
mRNA-decapping enzyme 1A; decapping enzyme hDcp1a; transcription factor SMIF; DCP1 decapping enzyme homolog A; putative protein product of Nbla00360; Smad4-interacting transcriptional co-activator
UniProt Protein Name
mRNA-decapping enzyme 1A
UniProt Synonym Protein Names
Smad4-interacting transcriptional co-activator; Transcription factor SMIF
UniProt Synonym Gene Names
UniProt Entry Name
DCP1A_HUMAN
NCBI Summary for DCP1A
Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Comments for DCP1A
DCP1A: a decapping enzyme. Plays a role in general and regulated mRNA decay. Apparently plays a role in the nonsense-mediated decay pathway that rids cells of mRNAs containing premature termination codons. May function as a transactivator of SMAD4 that participates in TGF-beta signaling.
Protein type: RNA processing; Transcription, coactivator/corepressor; Hydrolase; EC 3.-.-.-
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component: membrane; nucleus; cytosol
Molecular Function: identical protein binding; protein binding; hydrolase activity
Biological Process: mRNA catabolic process, nonsense-mediated decay; gene expression; mRNA catabolic process, deadenylation-dependent decay
Research Articles on DCP1A
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