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TNFRSF6B elisa kit :: Human DCR3/TNFRSF6B PicoKine ELISA Kit

Scan QR to view Datasheet Catalog #    MBS177623
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
96-Strip-Wells  /  $425 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DCR3/TNFRSF6B PicoKine, ELISA Kit

★Popular Item★
 Also Known As   

Human DCR3/TNFRSF6B PicoKine ELISA Kit

 Product Synonym Names    Tumor necrosis factor receptor superfamily member 6B; DcR3; Decoy Receptor 3; Decoy receptor for Fas ligand; DJ583P15.1.1; M68; M68E; OTTHUMP00000031583; TNF6B_HUMAN; TNFRSF6B; TR6; Tumor necrosis factor receptor superfamily member 6B; Tumor necrosis factor receptor superfamily member 6b decoy; Tumor necrosis factor receptor superfamily member 6b decoy; UNQ186/PRO212 ; tumor necrosis factor receptor superfamily, member 6b, decoy
 Product Gene Name   

TNFRSF6B elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    603361
 3D Structure    ModBase 3D Structure for O95407
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 Species Reactivity    Human
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 Specificity    Natural and recombinant human OCR3
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 Samples    Cell culture supernates, cell Iysates, tissue homogenates, serum and plasma (heparin, EDTA)
 Assay Type    Quantitative Sandwich
 Detection Range    156pg!ml-10000pg/ml
 Sensitivity    < 10pg/ml
 Intra-assay Precision    Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
 Inter-assay Precision    Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay rrecision.
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 Preparation and Storage    Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TNFRSF6B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TNFRSF6B purchase    MBS177623 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the DCR3/TNFRSF6B PicoKine, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 156pg!ml-10000pg/ml in biological research samples containing TNFRSF6B, with an estimated sensitivity of < 10pg/ml. The ELISA analytical biochemical technique of the MBS177623 kit is based on TNFRSF6B antibody-TNFRSF6B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TNFRSF6B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TNFRSF6B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Cell culture supernates, cell Iysates, tissue homogenates, serum and plasma (heparin, EDTA). Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TNFRSF6B elisa kit

   Principle of the Assay: The human DCR3 ELISA Kit was based on standard sandwich enzyme-lirked immune-sorbent assay technology. A monoclonal antibody from mouse specific for DCR3 has been precoate-J onto 96-well plates. Standards (Expression system for standard: sf21. Immunogen sequence: V24 - H300) and test samples are added to the wells, a biotinylated detection polyc!onal antibody from goat specific for DCR3 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the human DCR3 amount of sample captured in plate.

Background/Introduction: Decoy receptor 3 (Dcr3), also known as tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), TR6 and M68, is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand-inducedapoptosis. This gene belongs to the tumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes with death receptors for ligand binding. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL 1A. Overexpression of this gene has be':!n noted in various tumors e.g. gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes.
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 Typical Testing Data/Standard Curve (for reference only) of TNFRSF6B elisa kit    Human DCR3/TNFRSF6B PicoKine ELISA Kit standard curve
TNFRSF6B elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS177623. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TNFRSF6B. It may not necessarily be applicable to this product.
 NCBI GI #    4507585
 NCBI GeneID    8771
 NCBI Accession #    NP_003814.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003823.3 [Other Products]
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 UniProt Primary Accession #    O95407 [Other Products]
 UniProt Related Accession #    O95407 [Other Products]
 Molecular Weight    32,680 Da [Similar Products]
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 6B
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily member 6b
 NCBI Official Symbol    TNFRSF6B [Similar Products]
 NCBI Official Synonym Symbols   
M68; TR6; DCR3; M68E; DJ583P15.1.1
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 6B
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 6B
 UniProt Synonym Protein Names   
Decoy receptor 3; DcR3; Decoy receptor for Fas ligand; M68
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF6B [Similar Products]
 UniProt Synonym Gene Names    DCR3; TR6; DcR3 [Similar Products]
 UniProt Entry Name    TNF6B_HUMAN
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 NCBI Summary for TNFRSF6B    This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
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 UniProt Comments for TNFRSF6B    TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: extracellular region; extracellular space; integral to plasma membrane

Molecular Function: protein binding; receptor activity; tumor necrosis factor receptor activity

Biological Process: immune response; inflammatory response; multicellular organismal development; negative regulation of apoptosis; positive regulation of MAPKKK cascade; regulation of cell proliferation; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway
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 Research Articles on TNFRSF6B    1. tumour markers DcR3 and growth/differentiation factor (GDF)15 from 100 mul human serum, were quantified.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TNFRSF6B elisa kitPathways associated with TNFRSF6B elisa kit
 Reference Product  PubMed Publications
 FASLG elisa kit  >22 publications with TNFRSF6B and FASLG
 TNFSF15 elisa kit  >17 publications with TNFRSF6B and TNFSF15
 TNFSF14 elisa kit  >17 publications with TNFRSF6B and TNFSF14
 TNFRSF10C elisa kit  >2 publications with TNFRSF6B and TNFRSF10C
 Products by Pathway  Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 TNFR2 Non-canonical NF-kB Pathway antibodies  TNFR2 Non-canonical NF-kB Pathway Diagram
 TNFs Bind Their Physiological Receptors Pathway antibodies  TNFs Bind Their Physiological Receptors Pathway Diagram
Diseases associated with TNFRSF6B elisa kitOrgans/Tissues associated with TNFRSF6B elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >147 publications with TNFRSF6B and Necrosis
 Carcinoma Antibodies  >36 publications with TNFRSF6B and Carcinoma
 Adenocarcinoma Antibodies  >23 publications with TNFRSF6B and Adenocarcinoma
 Liver Neoplasms Antibodies  >8 publications with TNFRSF6B and Liver Neoplasms
 Nervous System Diseases Antibodies  >8 publications with TNFRSF6B and Nervous System Diseases
 Neoplasm Invasiveness Antibodies  >6 publications with TNFRSF6B and Neoplasm Invasiveness
 Carcinoma, Hepatocellular Antibodies  >5 publications with TNFRSF6B and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >4 publications with TNFRSF6B and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >4 publications with TNFRSF6B and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with TNFRSF6B and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >11 publications with TNFRSF6B and Lung
 Kidney Antibodies  >10 publications with TNFRSF6B and Kidney
 Stomach Antibodies  >8 publications with TNFRSF6B and Stomach
 Vascular Antibodies  >8 publications with TNFRSF6B and Vascular
 Skin Antibodies  >5 publications with TNFRSF6B and Skin
 Pancreas Antibodies  >5 publications with TNFRSF6B and Pancreas
 Brain Antibodies  >4 publications with TNFRSF6B and Brain
 Bone Antibodies  >4 publications with TNFRSF6B and Bone
 Intestine Antibodies  >3 publications with TNFRSF6B and Intestine
 Spleen Antibodies  >3 publications with TNFRSF6B and Spleen
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