NP_001128181.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,674 Da
NCBI Official Full Name
protein DEK isoform 2
NCBI Official Synonym Full Names
DEK proto-oncogene
NCBI Official Synonym Symbols
NCBI Protein Information
protein DEK; DEK oncogene (DNA binding)
UniProt Protein Name
Protein DEK
UniProt Entry Name
DEK_HUMAN
NCBI Summary for DEK
This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
UniProt Comments for DEK
DEK: a ubiquitous protein with a SAP domain, which is found in a variety of nuclear proteins involved in transcription, DNA repair, RNA processing or apoptotic chromatin degradation. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA and is also involved in splice site selection during mRNA processing. A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemias (AML).
Protein type: RNA splicing; Oncoprotein; Histone-binding; DNA replication; DNA-binding
Chromosomal Location of Human Ortholog: 6p22.3
Cellular Component: contractile fiber; nucleus
Molecular Function: DNA binding; histone binding
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; chromatin modification; viral genome replication; signal transduction
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Products associated with DEK elisa kit
Diseases associated with DEK elisa kit
Organs/Tissues associated with DEK elisa kit
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