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DKK2 elisa kit :: Human DKK2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2505377
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DKK2, ELISA Kit

★Popular Item★
 Also Known As   

Human DKK2 (Dickkopf Related Protein 2) ELISA Kit

 Product Gene Name   

DKK2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS2505377 COA    COA PDF
 OMIM    605415
 3D Structure    ModBase 3D Structure for Q9UBU2
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and some recombinant Human DKK2. No significant crossreactivity or interference between Human DKK2 and analogues was observed.
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 Samples    Serum, plasma and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    0.16-10 ng/mL
 Sensitivity    Human DKK2 is 0.10 ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of DKK2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for DKK2 purchase    MBS2505377 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the DKK2, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.16-10 ng/mL in biological research samples containing DKK2, with an estimated sensitivity of Human DKK2 is 0.10 ng/mL. The ELISA analytical biochemical technique of the MBS2505377 kit is based on DKK2 antibody-DKK2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DKK2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DKK2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for DKK2 elisa kit

   Intended Uses: This ELISA kit can be applied to the in vitro quantitative determination of Human DKK2 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been precoated with an antibody specific to Human DKK2. Standards or samples are added to appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibodies specific for Human DKK2 and Avidin-Horseradish Peroxidase (HRP) conjugate are added to each micro plate well successively and incubated. After incubation, free components are washed away. Then the Substrate Reagent is added to each well, only those wells that contain Human DKK2, biotinylated detection antibody and Avidin- HRP conjugate will appear blue in color. The enzyme-substrate reaction will be terminated by adding Stop Solution and appears yellow in color. The optical density (OD) can be measured with spectrophotometry at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Human DKK2. The concentration of Human DKK2 in samples can be calculated by comparing the OD of the samples with the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of DKK2 elisa kit    DKK2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2505377. Click to request current manual
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NCBI/Uniprot data below describe general gene information for DKK2. It may not necessarily be applicable to this product.
 NCBI GI #    7657023
 NCBI GeneID    27123
 NCBI Accession #    NP_055236.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014421.2 [Other Products]
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 UniProt Primary Accession #    Q9UBU2 [Other Products]
 UniProt Secondary Accession #    Q9UIU3; A0AVE9; B2R6S7 [Other Products]
 UniProt Related Accession #    Q9UBU2 [Other Products]
 Molecular Weight    28,447 Da
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 NCBI Official Full Name    dickkopf-related protein 2
 NCBI Official Synonym Full Names    dickkopf WNT signaling pathway inhibitor 2
 NCBI Official Symbol    DKK2 [Similar Products]
 NCBI Official Synonym Symbols   
DKK-2
[Similar Products]
 NCBI Protein Information    dickkopf-related protein 2; dickkopf 2 homolog; dickkopf homolog 2; dickkopf related protein-2; dickkopf-2; hDkk-2
 UniProt Protein Name    Dickkopf-related protein 2
 Protein Family    Dickkopf-related protein
 UniProt Gene Name    DKK2 [Similar Products]
 UniProt Synonym Gene Names    Dickkopf-2; Dkk-2; hDkk-2 [Similar Products]
 UniProt Entry Name    DKK2_HUMAN
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 NCBI Summary for DKK2    This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]
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 UniProt Comments for DKK2    DKK2: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP5 and LRP6. Expressed in heart, brain, skeletal muscle and lung. Belongs to the dickkopf family.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: extracellular space

Biological Process: Wnt receptor signaling pathway; multicellular organismal development
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 Research Articles on DKK2    1. We found 1 DKK2 SNP to be significantly associated with alcohol-related harm in alcoholic subjects
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DKK2 elisa kitPathways associated with DKK2 elisa kit
 Reference Product  PubMed Publications
 DKK1 elisa kit  >62 publications with DKK2 and DKK1
 LRP6 elisa kit  >21 publications with DKK2 and LRP6
 LRP5 elisa kit  >18 publications with DKK2 and LRP5
 WNT6 elisa kit  >6 publications with DKK2 and WNT6
 WNT7B elisa kit  >6 publications with DKK2 and WNT7B
 KREMEN1 elisa kit  >4 publications with DKK2 and KREMEN1
 WNT2B elisa kit  >3 publications with DKK2 and WNT2B
 KREMEN2 elisa kit  >2 publications with DKK2 and KREMEN2
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Presenilin Action In Notch And Wnt Signaling Pathway antibodies  Presenilin Action In Notch And Wnt Signaling Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies  XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram
Diseases associated with DKK2 elisa kitOrgans/Tissues associated with DKK2 elisa kit
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >8 publications with DKK2 and Adenocarcinoma
 Inflammation Antibodies  >7 publications with DKK2 and Inflammation
 Liver Neoplasms Antibodies  >3 publications with DKK2 and Liver Neoplasms
 Kidney Diseases Antibodies  >3 publications with DKK2 and Kidney Diseases
 Disease Models, Animal Antibodies  >3 publications with DKK2 and Disease Models, Animal
 Liver Diseases Antibodies  >3 publications with DKK2 and Liver Diseases
 Fibrosis Antibodies  >3 publications with DKK2 and Fibrosis
 Neoplasm Metastasis Antibodies  >3 publications with DKK2 and Neoplasm Metastasis
 Congenital Abnormalities Antibodies  >3 publications with DKK2 and Congenital Abnormalities
 Carcinoma, Hepatocellular Antibodies  >3 publications with DKK2 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >39 publications with DKK2 and Bone
 Embryonic Tissue Antibodies  >13 publications with DKK2 and Embryonic Tissue
 Eye Antibodies  >10 publications with DKK2 and Eye
 Liver Antibodies  >9 publications with DKK2 and Liver
 Vascular Antibodies  >5 publications with DKK2 and Vascular
 Heart Antibodies  >4 publications with DKK2 and Heart
 Uterus Antibodies  >4 publications with DKK2 and Uterus
 Brain Antibodies  >4 publications with DKK2 and Brain
 Lung Antibodies  >2 publications with DKK2 and Lung
 Placenta Antibodies  >1 publications with DKK2 and Placenta
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