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DCLRE1C elisa kit :: Human DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9337255 DCLRE1C elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) (DCLRE1C), ELISA Kit

 Also Known As   

Human Protein artemis, DCLRE1C ELISA Kit

 Product Synonym Names    Human Protein artemis (DCLRE1C) ELISA kit; RP11-398C13.5; A-SCID; DCLREC1C; FLJ11360; FLJ36438; RS-SCID; SCIDA; SNM1C; OTTHUMP00000019166; OTTHUMP00000019167; OTTHUMP00000019168; OTTHUMP00000019170; OTTHUMP00000019171; OTTHUMP00000019172; artemis; DNA cross-link repair 1C (PSO2 homolog; S. cerevisiae)
 Product Gene Name   

DCLRE1C elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    605988
 3D Structure    ModBase 3D Structure for Q96SD1
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of DCLRE1C elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for DCLRE1C purchase    MBS9337255 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) (DCLRE1C) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DCLRE1C. The ELISA analytical biochemical technique of the MBS9337255 kit is based on DCLRE1C antibody-DCLRE1C antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DCLRE1C antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DCLRE1C. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for DCLRE1C. It may not necessarily be applicable to this product.
 NCBI GI #    76496497
 NCBI GeneID    64421
 NCBI Accession #    NP_001029027.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001033855.2 [Other Products]
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 UniProt Primary Accession #    Q96SD1 [Other Products]
 UniProt Secondary Accession #    Q1HCL2; Q5JSR4; Q5JSR5; Q5JSR7; Q5JSR8; Q5JSR9; Q5JSS0; Q5JSS7; Q6PK14; Q8N101; D3DRT6 [Other Products]
 UniProt Related Accession #    Q96SD1 [Other Products]
 Molecular Weight    78,436 Da
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 NCBI Official Full Name    protein artemis isoform a
 NCBI Official Synonym Full Names    DNA cross-link repair 1C
 NCBI Official Symbol    DCLRE1C [Similar Products]
 NCBI Official Synonym Symbols   
SCIDA; SNM1C; A-SCID; RS-SCID; DCLREC1C
[Similar Products]
 NCBI Protein Information    protein artemis; SNM1 homolog C; SNM1-like protein; severe combined immunodeficiency, type a (Athabascan); DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)
 UniProt Protein Name    Protein artemis
 UniProt Synonym Protein Names   
DNA cross-link repair 1C protein; Protein A-SCID; SNM1 homolog C; hSNM1C; SNM1-like protein
 Protein Family    Protein artemis
 UniProt Gene Name    DCLRE1C [Similar Products]
 UniProt Synonym Gene Names    ARTEMIS; ASCID; SCIDA; SNM1C; hSNM1C [Similar Products]
 UniProt Entry Name    DCR1C_HUMAN
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 NCBI Summary for DCLRE1C    This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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 UniProt Comments for DCLRE1C    Artemis: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ. Defects in DCLRE1C are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell- negative/NK-cell-positive with sensitivity to ionizing radiation (RSSCID). SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T- cell development. Individuals affected by RS-SCID show defects in the DNA repair machinery necessary for coding joint formation and the completion of V(D)J recombination. A subset of cells from such patients show increased radiosensitivity. Defects in DCLRE1C are the cause of severe combined immunodeficiency Athabaskan type (SCIDA). SCIDA is a variety of RS-SCID caused by a founder mutation in Athabascan- speaking native Americans, being inherited as an autosomal recessive trait with an estimated gene frequency of 2.1% in the Navajo population. Affected individuals exhibit clinical symptoms and defects in DNA repair comparable to those seen in RS-SCID. Defects in DCLRE1C are a cause of Omenn syndrome (OS). OS is characterized by severe combined immunodeficiency associated with erythrodermia, hepatosplenomegaly, lymphadenopathy and alopecia. Affected individuals have elevated T-lymphocyte counts with a restricted T- cell receptor (TCR) repertoire. They also generally lack B- lymphocytes, but have normal natural killer (NK) cell function (T+ B- NK+). Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Deoxyribonuclease; DNA repair, damage; EC 3.1.-.-

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: nucleus

Molecular Function: 5'-3' exonuclease activity; single-stranded DNA specific endodeoxyribonuclease activity

Biological Process: V(D)J recombination; B cell differentiation; double-strand break repair; response to ionizing radiation; telomere maintenance; DNA catabolic process, endonucleolytic

Disease: Omenn Syndrome; Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
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 Research Articles on DCLRE1C    1. the 5'-exonuclease is intrinsic to ARTEMIS, making it relevant to the role of ARTEMIS in nonhomologous DNA end joining
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DCLRE1C elisa kitPathways associated with DCLRE1C elisa kit
 Reference Product  PubMed Publications
 PRKDC elisa kit  >36 publications with DCLRE1C and PRKDC
 ATM elisa kit  >25 publications with DCLRE1C and ATM
 MRE11A elisa kit  >5 publications with DCLRE1C and MRE11A
 NBN elisa kit  >4 publications with DCLRE1C and NBN
 BRCA1 elisa kit  >4 publications with DCLRE1C and BRCA1
 TP53BP1 elisa kit  >3 publications with DCLRE1C and TP53BP1
 RAD50 elisa kit  >2 publications with DCLRE1C and RAD50
 Products by Pathway  Pathway Diagram
 Non-homologous End-joining Pathway antibodies  Non-homologous End-joining Pathway Diagram
 Non-homologous End-joining Pathway antibodies  Non-homologous End-joining Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
Diseases associated with DCLRE1C elisa kitOrgans/Tissues associated with DCLRE1C elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >12 publications with DCLRE1C and Neoplasms
 Severe combined immunodeficiency with sensitivity to ionizing radiation Antibodies  >6 publications with DCLRE1C and Severe combined immunodeficiency with sensitivity to ionizing radiation
 Bone Marrow Diseases Antibodies  >5 publications with DCLRE1C and Bone Marrow Diseases
 Nervous System Diseases Antibodies  >4 publications with DCLRE1C and Nervous System Diseases
 Vascular Diseases Antibodies  >4 publications with DCLRE1C and Vascular Diseases
 Leukemia, Lymphoid Antibodies  >3 publications with DCLRE1C and Leukemia, Lymphoid
 Drug Toxicity Antibodies  >3 publications with DCLRE1C and Drug Toxicity
 Inflammation Antibodies  >3 publications with DCLRE1C and Inflammation
 Sarcoma Antibodies  >2 publications with DCLRE1C and Sarcoma
 Leukopenia Antibodies  >2 publications with DCLRE1C and Leukopenia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >38 publications with DCLRE1C and Blood
 Bone Marrow Antibodies  >11 publications with DCLRE1C and Bone Marrow
 Skin Antibodies  >5 publications with DCLRE1C and Skin
 Thymus Antibodies  >4 publications with DCLRE1C and Thymus
 Kidney Antibodies  >4 publications with DCLRE1C and Kidney
 Heart Antibodies  >1 publications with DCLRE1C and Heart
 Muscle Antibodies  >1 publications with DCLRE1C and Muscle
 Spleen Antibodies  >1 publications with DCLRE1C and Spleen
 Prostate Antibodies  >1 publications with DCLRE1C and Prostate
 Lung Antibodies  >1 publications with DCLRE1C and Lung
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