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DERL2 elisa kit :: Human Der1-like domain family, member 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9322912 DERL2 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Der1-like domain family, member 2 (DERL2), ELISA Kit

 Also Known As   

Human Derlin-2, DERL2 ELISA Kit

 Product Synonym Names    Human Derlin-2 (DERL2) ELISA kit; CGI-101; F-LAN-1; F-LANa; FLANa; carcinoma related; derlin-2; Der1-like domain family; member 2
 Product Gene Name   

DERL2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    610304
 3D Structure    ModBase 3D Structure for Q9GZP9
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of DERL2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for DERL2 purchase    MBS9322912 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Der1-like domain family, member 2 (DERL2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DERL2. The ELISA analytical biochemical technique of the MBS9322912 kit is based on DERL2 antibody-DERL2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DERL2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DERL2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for DERL2. It may not necessarily be applicable to this product.
 NCBI GI #    31455614
 NCBI GeneID    51009
 NCBI Accession #    NP_057125.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_016041.3 [Other Products]
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 UniProt Primary Accession #    Q9GZP9 [Other Products]
 UniProt Secondary Accession #    Q9Y3A7 [Other Products]
 UniProt Related Accession #    Q9GZP9 [Other Products]
 Molecular Weight    27,567 Da
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 NCBI Official Full Name    derlin-2
 NCBI Official Synonym Full Names    derlin 2
 NCBI Official Symbol    DERL2 [Similar Products]
 NCBI Official Synonym Symbols   
FLANa; F-LANa; CGI-101; F-LAN-1
[Similar Products]
 NCBI Protein Information    derlin-2; DERtrin-2; carcinoma related; der1-like protein 2; Der1-like domain family, member 2; degradation in endoplasmic reticulum protein 2
 UniProt Protein Name    Derlin-2
 UniProt Synonym Protein Names   
Degradation in endoplasmic reticulum protein 2; DERtrin-2; Der1-like protein 2; F-LAN-1; F-LANa
 Protein Family    Derlin
 UniProt Gene Name    DERL2 [Similar Products]
 UniProt Synonym Gene Names    DER2; FLANA; CGI-101; SBBI53; DERtrin-2 [Similar Products]
 UniProt Entry Name    DERL2_HUMAN
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 NCBI Summary for DERL2    Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for DERL2    DERL2: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation. Belongs to the derlin family.

Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; late endosome; early endosome; integral to endoplasmic reticulum membrane

Molecular Function: protein binding

Biological Process: retrograde protein transport, ER to cytosol; ER-associated protein catabolic process; suckling behavior; unfolded protein response; positive regulation of cell proliferation; positive regulation of cell growth
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 Research Articles on DERL2    1. derlin2 functions with HRD1 in ERAD of certain substrates independent of their glycosylation status.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with DERL2 elisa kitDiseases associated with DERL2 elisa kit
 Products by Pathway  Pathway Diagram
 HRD1/SEL1 ERAD Complex Pathway antibodies  HRD1/SEL1 ERAD Complex Pathway Diagram
 HRD1/SEL1 ERAD Complex Pathway antibodies  HRD1/SEL1 ERAD Complex Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with DERL2 and Carcinoma
 Neoplasms Antibodies  >2 publications with DERL2 and Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with DERL2 and Carcinoma, Hepatocellular
 Melanoma Antibodies  >1 publications with DERL2 and Melanoma
 Neoplasms, Experimental Antibodies  >1 publications with DERL2 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >1 publications with DERL2 and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >1 publications with DERL2 and Adenocarcinoma
 Liver Diseases Antibodies  >1 publications with DERL2 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with DERL2 and Liver Neoplasms
Organs/Tissues associated with DERL2 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with DERL2 and Liver
 Blood Antibodies  >2 publications with DERL2 and Blood
 Kidney Antibodies  >1 publications with DERL2 and Kidney
 Brain Antibodies  >1 publications with DERL2 and Brain
 Embryonic Tissue Antibodies  >1 publications with DERL2 and Embryonic Tissue
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