NP_037484.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
109,773 Da
NCBI Official Full Name
dermatan-sulfate epimerase
NCBI Official Synonym Full Names
dermatan sulfate epimerase
NCBI Official Synonym Symbols
DSEP; DSEPI; SART2; EDSMC2; SART-2 [Similar Products]
NCBI Protein Information
dermatan-sulfate epimerase; DS epimerase; chondroitin-glucuronate 5-epimerase; squamous cell carcinoma antigen recognized by T-cells 2
UniProt Protein Name
Dermatan-sulfate epimerase
UniProt Synonym Protein Names
Chondroitin-glucuronate 5-epimerase; Squamous cell carcinoma antigen recognized by T-cells 2; SART-2
UniProt Synonym Gene Names
UniProt Entry Name
DSE_HUMAN
NCBI Summary for DS
The protein encoded by this gene is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is localized to the endoplasmic reticulum. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DS
SART2: Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Belongs to the dermatan-sulfate isomerase family.
Protein type: Isomerase; Membrane protein, integral; Endoplasmic reticulum; Glycan Metabolism - chondroitin sulfate biosynthesis; EC 5.1.3.19; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6q22
Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum; integral to membrane
Molecular Function: chondroitin-glucuronate 5-epimerase activity
Biological Process: chondroitin sulfate metabolic process; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; heparan sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; pathogenesis; dermatan sulfate biosynthetic process
Disease: Ehlers-danlos Syndrome, Musculocontractural Type 2
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Pathways associated with DS elisa kit
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