AAH63291.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Related Accession #
Molecular Weight
93,769 Da
NCBI Official Full Name
Desmocollin 2
NCBI Official Synonym Full Names
desmocollin 2
NCBI Official Synonym Symbols
DG2; DSC3; CDHF2; ARVD11; DGII/III [Similar Products]
NCBI Protein Information
desmocollin-2
UniProt Protein Name
Desmocollin-2
UniProt Synonym Protein Names
Cadherin family member 2; Desmocollin-3; Desmosomal glycoprotein II; Desmosomal glycoprotein III
UniProt Synonym Gene Names
UniProt Entry Name
DSC2_HUMAN
NCBI Summary for DSC2
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
UniProt Comments for DSC2
DSC2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11); also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component: desmosome; cell-cell adherens junction; integral to membrane; plasma membrane; cytoplasmic vesicle
Molecular Function: protein binding; calcium ion binding
Biological Process: cell adhesion; homophilic cell adhesion; cellular response to starvation
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 11
Research Articles on DSC2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with DSC2 elisa kit
Pathways associated with DSC2 elisa kit
Diseases associated with DSC2 elisa kit
Organs/Tissues associated with DSC2 elisa kit
|