NP_001177255.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
86,045 Da
NCBI Official Full Name
microprocessor complex subunit DGCR8 isoform 2
NCBI Official Synonym Full Names
DGCR8 microprocessor complex subunit
NCBI Protein Information
microprocessor complex subunit DGCR8; DiGeorge syndrome critical region 8; DiGeorge syndrome critical region gene 8
UniProt Protein Name
Microprocessor complex subunit DGCR8
UniProt Synonym Protein Names
DiGeorge syndrome critical region 8
UniProt Synonym Gene Names
UniProt Entry Name
DGCR8_HUMAN
NCBI Summary for DGCR8
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
UniProt Comments for DGCR8
DGCR8: a double strand RNA binding protein (dsRBP) which is essential for the first processing step of primary miRNAs (pri-miRNAs). Apparently binds and is activated by heme. A nuclear complex of Drosha with DGCR8 cleaves pri-miRNA substrates into 60-70 nucleotide intermediates (pre-miRNA), thus initiating the microRNA maturation process. Drosha provides the catalytic site for this cleavage, whereas DGCR8 (Pasha) anchors substrate pri-miRNAs. Pre-miRNAs are then processed by the cytoplasmic Dicer-TRBP complex to approximately 20-22 nt mature miRNAs.
Protein type: RNA-binding; Nucleolus; RNA processing
Chromosomal Location of Human Ortholog: 22q11.2
Cellular Component: microtubule cytoskeleton; nucleoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; ribonuclease III activity; protein homodimerization activity; metal ion binding; double-stranded RNA binding
Biological Process: gene expression; primary microRNA processing
Disease: Velocardiofacial Syndrome
Research Articles on DGCR8
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Products associated with DGCR8 elisa kit
Pathways associated with DGCR8 elisa kit
Diseases associated with DGCR8 elisa kit
Organs/Tissues associated with DGCR8 elisa kit
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