NP_001926.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
88,279 Da
NCBI Official Full Name
dipeptidyl peptidase 4
NCBI Official Synonym Full Names
dipeptidyl peptidase 4
NCBI Official Synonym Symbols
CD26; ADABP; ADCP2; DPPIV; TP103 [Similar Products]
NCBI Protein Information
dipeptidyl peptidase 4
UniProt Protein Name
Dipeptidyl peptidase 4
UniProt Synonym Protein Names
ADABP; Adenosine deaminase complexing protein 2; ADCP-2
UniProt Synonym Gene Names
UniProt Entry Name
DPP4_HUMAN
NCBI Summary for DPP4
The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
UniProt Comments for DPP4
DPP4: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF- kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Belongs to the peptidase S9B family. DPPIV subfamily.
Protein type: Cell surface; EC 3.4.14.5; Cell adhesion; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 2q24.3
Cellular Component: apical plasma membrane; cell surface; endocytic vesicle; focal adhesion; integral to membrane; intercellular canaliculus; lamellipodium; lipid raft; lysosomal membrane; membrane; plasma membrane
Molecular Function: dipeptidyl-peptidase activity; identical protein binding; protease binding; protein binding; protein homodimerization activity; receptor binding; serine-type endopeptidase activity; serine-type peptidase activity; viral receptor activity
Biological Process: behavioral fear response; endothelial cell migration; entry of virus into host cell; positive regulation of cell proliferation; proteolysis; regulation of cell-cell adhesion mediated by integrin; response to hypoxia; T cell activation; T cell costimulation
Research Articles on DPP4
Precautions
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Diseases associated with DPP4 elisa kit
Organs/Tissues associated with DPP4 elisa kit
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