NP_004410.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,047 Da
NCBI Official Full Name
dual specificity protein phosphatase 5
NCBI Official Synonym Full Names
dual specificity phosphatase 5
NCBI Official Synonym Symbols
NCBI Protein Information
dual specificity protein phosphatase 5
UniProt Protein Name
Dual specificity protein phosphatase 5
UniProt Synonym Protein Names
Dual specificity protein phosphatase hVH3
UniProt Synonym Gene Names
UniProt Entry Name
DUS5_HUMAN
NCBI Summary for DUSP5
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]
UniProt Comments for DUSP5
DUSP5: a dual-specificity protein phosphatase containing one Rhodanese domain. Is a direct transcriptional target of p53. Targets include phosphorylated MAP kinases. Overexpression suppresses the growth of several types of human cancer cells. Induced by IL-2, IL-7, and IL-15 but not IL-4 in T cells.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; EC 3.1.3.16; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 10q25
Cellular Component: nucleus
Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process: endoderm formation; protein amino acid dephosphorylation; inactivation of MAPK activity
Research Articles on DUSP5
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Products associated with DUSP5 elisa kit
Pathways associated with DUSP5 elisa kit
Diseases associated with DUSP5 elisa kit
Organs/Tissues associated with DUSP5 elisa kit
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