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ENG elisa kit :: Human ENG ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2516343
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ENG, ELISA Kit

★Popular Item★
 Also Known As   

Human ENG(Endoglin)ELISA Kit

 Product Gene Name   

ENG elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    131195
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 Species Reactivity    Human
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 Specificity    This kit recognizes natural and recombinantHumanh-HCG. No significant cross-reactivity or interference between Humanh-HCG and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156-10ng/mL
 Sensitivity    Min: 0.094ng/mL; Max: 10ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ENG elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ENG purchase    MBS2516343 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ENG, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10ng/mL in biological research samples containing ENG, with an estimated sensitivity of Min: 0.094ng/mL; Max: 10ng/mL. The ELISA analytical biochemical technique of the MBS2516343 kit is based on ENG antibody-ENG antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ENG antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ENG. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ENG elisa kit

   Intended Uses: This ELISA kit applies to the invitro quantitative determination of Humanh-HCGconcentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to h-HCG. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for h-HCGand Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain h-HCG, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of h-HCG.You can calculate the concentration of h-HCGin the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of ENG elisa kit    ENG elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2516343. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ENG. It may not necessarily be applicable to this product.
 NCBI GI #    15679936
 NCBI GeneID    2022
 NCBI Accession #    AAH14271.1 [Other Products]
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 UniProt Secondary Accession #    Q14248; Q14926; Q5T9C0 [Other Products]
 UniProt Related Accession #    P17813 [Other Products]
 Molecular Weight    67,542 Da
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 NCBI Official Full Name    ENG protein
 NCBI Official Synonym Full Names    endoglin
 NCBI Official Symbol    ENG [Similar Products]
 NCBI Official Synonym Symbols   
END; HHT1; ORW1
[Similar Products]
 NCBI Protein Information    endoglin; CD105 antigen
 UniProt Protein Name    Endoglin
 UniProt Synonym Protein Names   
CD_antigen: CD105
 Protein Family    Endoglin
 UniProt Gene Name    ENG [Similar Products]
 UniProt Synonym Gene Names    END [Similar Products]
 UniProt Entry Name    EGLN_HUMAN
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 NCBI Summary for ENG    This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
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 UniProt Comments for ENG    ENG: Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently. Interacts with TCTEX1D4. Interacts with ARRB2. Endoglin is restricted to endothelial cells in all tissues except bone marrow. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: nucleoplasm; extracellular space; focal adhesion; cell surface; cytoplasm; receptor complex; external side of plasma membrane

Molecular Function: transforming growth factor beta receptor activity; protein binding; protein homodimerization activity; glycosaminoglycan binding; transmembrane receptor activity; transforming growth factor beta binding; galactose binding; punt binding; activin binding; transforming growth factor beta receptor, cytoplasmic mediator activity

Biological Process: wound healing; positive regulation of collagen biosynthetic process; cell motility involved in cell locomotion; positive regulation of systemic arterial blood pressure; negative regulation of transcription from RNA polymerase II promoter; response to corticosteroid stimulus; BMP signaling pathway; extracellular matrix disassembly; smooth muscle development; central nervous system vasculogenesis; regulation of transforming growth factor beta receptor signaling pathway; venous blood vessel morphogenesis; regulation of transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; negative regulation of protein amino acid autophosphorylation; heart looping; vasculogenesis; cell adhesion; chronological cell aging; negative regulation of cell migration; positive regulation of BMP signaling pathway; regulation of cell adhesion; cell migration; negative regulation of nitric-oxide synthase activity; regulation of phosphorylation; regulation of cell proliferation; patterning of blood vessels; negative regulation of endothelial cell proliferation; response to hypoxia; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway

Disease: Telangiectasia, Hereditary Hemorrhagic, Of Rendu, Osler, And Weber
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 Research Articles on ENG    1. The S-endoglin isoform impairs monocytic differentiation into the pro-inflammatory M1 phenotype and contributes to the compromised status of macrophage functions during aging.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ENG elisa kitPathways associated with ENG elisa kit
 Reference Product  PubMed Publications
 TGFB1 elisa kit  >329 publications with ENG and TGFB1
 ACVRL1 elisa kit  >164 publications with ENG and ACVRL1
 BMP2 elisa kit  >131 publications with ENG and BMP2
 SMAD4 elisa kit  >50 publications with ENG and SMAD4
 HIF1A elisa kit  >38 publications with ENG and HIF1A
 TGFBR2 elisa kit  >6 publications with ENG and TGFBR2
 TGFBR1 elisa kit  >5 publications with ENG and TGFBR1
 GIPC1 elisa kit  >1 publications with ENG and GIPC1
 TGFBI elisa kit  >1 publications with ENG and TGFBI
 Products by Pathway  Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with ENG elisa kitOrgans/Tissues associated with ENG elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6390 publications with ENG and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >5575 publications with ENG and Cardiovascular Diseases
 Heart Diseases Antibodies  >2911 publications with ENG and Heart Diseases
 Breast Neoplasms Antibodies  >753 publications with ENG and Breast Neoplasms
 Disease Models, Animal Antibodies  >738 publications with ENG and Disease Models, Animal
 Inflammation Antibodies  >637 publications with ENG and Inflammation
 Hypertension Antibodies  >611 publications with ENG and Hypertension
 Liver Diseases Antibodies  >469 publications with ENG and Liver Diseases
 Atherosclerosis Antibodies  >440 publications with ENG and Atherosclerosis
 Necrosis Antibodies  >411 publications with ENG and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11158 publications with ENG and Blood
 Bone Antibodies  >7932 publications with ENG and Bone
 Brain Antibodies  >7840 publications with ENG and Brain
 Heart Antibodies  >7805 publications with ENG and Heart
 Muscle Antibodies  >6916 publications with ENG and Muscle
 Vascular Antibodies  >6797 publications with ENG and Vascular
 Nerve Antibodies  >2919 publications with ENG and Nerve
 Skin Antibodies  >2861 publications with ENG and Skin
 Connective Tissue Antibodies  >2405 publications with ENG and Connective Tissue
 Eye Antibodies  >2025 publications with ENG and Eye
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