NP_853510.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
25,287 Da
NCBI Official Full Name
GTPase ERas
NCBI Official Synonym Full Names
ES cell expressed Ras
NCBI Official Synonym Symbols
NCBI Protein Information
GTPase ERas; E-Ras; small GTPase protein E-Ras; embryonic stem cell-expressed Ras; v-Ha-ras Harvey rat sarcoma viral oncogene homolog 2; v-Ha-ras Harvey rat sarcoma viral oncogene homolog pseudogene
UniProt Protein Name
GTPase ERas
UniProt Synonym Protein Names
Embryonic stem cell-expressed Ras
UniProt Synonym Gene Names
UniProt Entry Name
RASE_HUMAN
NCBI Summary for ERAS
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]
UniProt Comments for ERAS
ERas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells. Belongs to the small GTPase superfamily. Ras family.
Protein type: G protein, monomeric, Ras; G protein; G protein, monomeric
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: plasma membrane
Molecular Function: GTP binding
Biological Process: small GTPase mediated signal transduction
Research Articles on ERAS
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Diseases associated with ERAS elisa kit
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