NP_001243212.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,803 Da
NCBI Official Full Name
endothelin-1 receptor isoform c
NCBI Official Synonym Full Names
endothelin receptor type A
NCBI Official Synonym Symbols
ETA; ET-A; ETAR; ETRA; ETA-R; hET-AR [Similar Products]
NCBI Protein Information
endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor
UniProt Protein Name
Endothelin-1 receptor
UniProt Synonym Protein Names
Endothelin A receptor; ET-A; ETA-R; hET-AR
UniProt Synonym Gene Names
UniProt Entry Name
EDNRA_HUMAN
NCBI Summary for ETRA
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
UniProt Comments for ETRA
EDNRA: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: 4q31.22
Cellular Component: nuclear membrane; integral to plasma membrane; T-tubule; plasma membrane; lipid raft
Molecular Function: endothelin receptor activity; protein binding; phosphoinositide phospholipase C activity
Biological Process: positive regulation of odontogenesis; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); neural crest cell development; metabolic process; heart development; smooth muscle cell proliferation; response to morphine; response to lipopolysaccharide; glucose transport; signal transduction; sensory perception of pain; enteric nervous system development; Rho protein signal transduction; regulation of epithelial cell proliferation; histamine secretion; negative regulation of cAMP biosynthetic process; elevation of cytosolic calcium ion concentration; smooth muscle contraction; fibroblast proliferation; regulation of blood pressure; protein kinase C activation; positive regulation of cell proliferation; artery smooth muscle contraction; penile erection; aging; vasoconstriction; in utero embryonic development; glomerular filtration; adenylate cyclase activation; respiratory gaseous exchange; patterning of blood vessels; cell proliferation; G-protein coupled receptor protein signaling pathway; phospholipase C activation; maternal process involved in parturition; response to hypoxia; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of protein amino acid phosphorylation; negative regulation of apoptosis; positive regulation of inflammatory response
Disease: Mandibulofacial Dysostosis With Alopecia; Migraine With Or Without Aura, Susceptibility To, 1
Research Articles on ETRA
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Pathways associated with ETRA elisa kit
Diseases associated with ETRA elisa kit
Organs/Tissues associated with ETRA elisa kit
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