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ESM1 elisa kit :: Human Endocan ELISA Kit

Scan QR to view Datasheet Catalog #    MBS824849
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
96 Tests  /  $470 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Endocan (ESM1), ELISA Kit

★Popular Item★
 Also Known As   

Human Endocan ELISA Kit

 Product Synonym Names    Endothelial cell-specific molecule 1; ESM-1
 Product Gene Name   

ESM1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    601521
 3D Structure    ModBase 3D Structure for Q9NQ30
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 Species Reactivity    Human
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 Specificity    The Human Endocan ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human Endocan proteins within the range of 31.2 pg/ml - 2000 pg/ml.
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 Samples    Cell Culture Supernatants, Serum, Plasma
 Sensitivity    <10 pg/mL
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 Preparation and Storage    Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ESM1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ESM1 purchase    MBS824849 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Endocan (ESM1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ESM1, with an estimated sensitivity of <10 pg/mL. The ELISA analytical biochemical technique of the MBS824849 kit is based on ESM1 antibody-ESM1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ESM1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ESM1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Cell Culture Supernatants, Serum, Plasma. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ESM1 elisa kit

   Principle of the Assay: MBS ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Human Endocan in Cell Culture Supernatants, Serum, Plasma. This assay employs an antibody specific for Human Endocan coated on a 96-well plate. Standards and samples are pipetted into the wells and Endocan present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Human Endocan antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of Endocan bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm.

Background: Endothelial cell-specific molecule 1, also known as Endocan, is a protein that in humans is encoded by the ESM1 gene. This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. ESM1 has been described as a specific biomarker of tip cells during neoangiogenesis by independent teams. Its expression has been shown to be increase in presence of pro-angiogenic growth factors such as VEGF (vascular endothelial growth factor) or FGF-2 (fibroblast growth factor 2).
 Applications Tested/Suitable for ESM1 elisa kit   

Sandwich ELISA (SE)

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 Typical Testing Data/Standard Curve (for reference only) of ESM1 elisa kit    ESM1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS824849. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ESM1. It may not necessarily be applicable to this product.
 NCBI GI #    208022668
 NCBI GeneID    11082
 NCBI Accession #    NP_001129076.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135604.1 [Other Products]
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 UniProt Primary Accession #    Q9NQ30 [Other Products]
 UniProt Secondary Accession #    Q15330; Q3V4E3; Q96ES3; B2R4G3 [Other Products]
 UniProt Related Accession #    Q9NQ30 [Other Products]
 Molecular Weight    14,513 Da
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 NCBI Official Full Name    endothelial cell-specific molecule 1 isoform b
 NCBI Official Synonym Full Names    endothelial cell-specific molecule 1
 NCBI Official Symbol    ESM1 [Similar Products]
 NCBI Official Synonym Symbols   
endocan
[Similar Products]
 NCBI Protein Information    endothelial cell-specific molecule 1; ESM-1
 UniProt Protein Name    Endothelial cell-specific molecule 1
 Protein Family    Endothelial cell-specific molecule
 UniProt Gene Name    ESM1 [Similar Products]
 UniProt Synonym Gene Names    ESM-1 [Similar Products]
 UniProt Entry Name    ESM1_HUMAN
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 NCBI Summary for ESM1    This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
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 UniProt Comments for ESM1    ESM1: May have potent implications in lung endothelial cell- leukocyte interactions. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: extracellular region

Molecular Function: integrin binding; insulin-like growth factor binding; hepatocyte growth factor receptor binding

Biological Process: positive regulation of cell proliferation; angiogenesis; regulation of cell growth; sprouting angiogenesis
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 Research Articles on ESM1    1. Suggest that increased circulating endocan levels represent a new marker in patients with essential hypertension.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ESM1 elisa kitPathways associated with ESM1 elisa kit
 Reference Product  PubMed Publications
 VEGFA elisa kit  >4 publications with ESM1 and VEGFA
 ITGAL elisa kit  >2 publications with ESM1 and ITGAL
 C9orf30 elisa kit  >1 publications with ESM1 and C9orf30
 ITGB2 elisa kit  >1 publications with ESM1 and ITGB2
 Products by Pathway  Pathway Diagram
 Gastric Cancer Network 1 Pathway antibodies  Gastric Cancer Network 1 Pathway Diagram
Diseases associated with ESM1 elisa kitOrgans/Tissues associated with ESM1 elisa kit
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >20 publications with ESM1 and Carcinoma
 Inflammation Antibodies  >18 publications with ESM1 and Inflammation
 Lung Diseases Antibodies  >11 publications with ESM1 and Lung Diseases
 Lung Neoplasms Antibodies  >10 publications with ESM1 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >10 publications with ESM1 and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >8 publications with ESM1 and Liver Neoplasms
 Liver Diseases Antibodies  >7 publications with ESM1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >6 publications with ESM1 and Carcinoma, Hepatocellular
 Hypertension Antibodies  >6 publications with ESM1 and Hypertension
 Neoplasms, Experimental Antibodies  >5 publications with ESM1 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >45 publications with ESM1 and Vascular
 Lung Antibodies  >19 publications with ESM1 and Lung
 Kidney Antibodies  >14 publications with ESM1 and Kidney
 Liver Antibodies  >9 publications with ESM1 and Liver
 Brain Antibodies  >7 publications with ESM1 and Brain
 Connective Tissue Antibodies  >3 publications with ESM1 and Connective Tissue
 Umbilical Cord Antibodies  >3 publications with ESM1 and Umbilical Cord
 Thyroid Antibodies  >2 publications with ESM1 and Thyroid
 Skin Antibodies  >2 publications with ESM1 and Skin
 Stomach Antibodies  >2 publications with ESM1 and Stomach
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