AAH63795.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,439 Da
NCBI Official Full Name
Estrogen-related receptor alpha
NCBI Official Synonym Full Names
estrogen-related receptor alpha
NCBI Official Synonym Symbols
ERR1; ERRa; ESRL1; NR3B1; ERRalpha [Similar Products]
NCBI Protein Information
steroid hormone receptor ERR1
UniProt Protein Name
Steroid hormone receptor ERR1
UniProt Synonym Protein Names
Estrogen receptor-like 1; Estrogen-related receptor alpha; ERR-alpha; Nuclear receptor subfamily 3 group B member 1
UniProt Synonym Gene Names
UniProt Entry Name
ERR1_HUMAN
NCBI Summary for ERRa
The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
UniProt Comments for ERRa
ERR1: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Belongs to the nuclear hormone receptor family. NR3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: nucleoplasm; microtubule cytoskeleton; intercellular bridge; nucleolus; nucleus
Molecular Function: protein domain specific binding; protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; steroid binding
Biological Process: mitochondrion organization and biogenesis; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; regulation of osteoblast differentiation; organelle organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; cartilage development; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; gene expression
Research Articles on ERRa
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Products associated with ERRa elisa kit
Pathways associated with ERRa elisa kit
Diseases associated with ERRa elisa kit
Organs/Tissues associated with ERRa elisa kit
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