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ERK elisa kit :: Human Extracellular Signal Regulated Kinase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS016155 ERK elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Extracellular Signal Regulated Kinase (ERK), ELISA Kit

★Popular Item★
 Also Known As   

Human Extracellular Signal Regulated Kinase ELISA Kit

 Product Gene Name   

ERK elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 22; NC_000022.10 (50691331..50700089, complement). Location: 22q13.33
 OMIM    602399
 3D Structure    ModBase 3D Structure for P53778
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 Species Reactivity    Human
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ERK elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ERK purchase    MBS016155 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Extracellular Signal Regulated Kinase (ERK) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ERK. The ELISA analytical biochemical technique of the MBS016155 kit is based on ERK antibody-ERK antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ERK antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ERK. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Sample Manual Insert of MBS016155. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ERK. It may not necessarily be applicable to this product.
 NCBI GI #    1486363
 NCBI GeneID    6300
 NCBI Accession #    CAA55984.1 [Other Products]
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 UniProt Primary Accession #    P53778 [Other Products]
 UniProt Secondary Accession #    Q14260; Q99588; Q99672 [Other Products]
 UniProt Related Accession #    P53778 [Other Products]
 Molecular Weight    41,940 Da
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 NCBI Official Full Name    extracellular signal regulated kinase
 NCBI Official Synonym Full Names    mitogen-activated protein kinase 12
 NCBI Official Symbol    MAPK12 [Similar Products]
 NCBI Official Synonym Symbols   
ERK3; ERK6; SAPK3; PRKM12; SAPK-3; P38GAMMA
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase 12; ERK-6; MAPK 12; MAP kinase 12; MAP kinase p38 gamma; stress-activated protein kinase 3; mitogen-activated protein kinase 3; extracellular signal-regulated kinase 6; mitogen-activated protein kinase p38 gamma
 UniProt Protein Name    Mitogen-activated protein kinase 12
 UniProt Synonym Protein Names   
Extracellular signal-regulated kinase 6; ERK-6; Mitogen-activated protein kinase p38 gamma; MAP kinase p38 gamma; Stress-activated protein kinase 3
 UniProt Gene Name    MAPK12 [Similar Products]
 UniProt Synonym Gene Names    ERK6; SAPK3; MAP kinase 12; MAPK 12; ERK-6 [Similar Products]
 UniProt Entry Name    MK12_HUMAN
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 NCBI Summary for ERK    Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ERK    P38G: a proline-directed ser/thr MAP kinase, and one of four p38 kinases that play important roles in cellular responses to inflammatory cytokines, DNA damage, oxidative stress, and some GPCRs. Directly activate transcription factors and of other downstream kinases including MSK1, MSK2, eEF2K, MK2, and PRAK. MSK1 and -2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli. MK2 and -3 control gene expression mostly at the post-transcriptional level. eEF2K is important for the elongation of mRNA during translation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17, which then cleaves the ectodomain of TGF-alpha family ligands, a process leading to the activation of EGFR signaling and cell proliferation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, CHOPO, p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. Interacts directly with HDAC3 interacts directly and selectively to repress ATF2 transcriptional activity, and regulate TNF gene expression in LPS-stimulated cells. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting that it may inhibit cell proliferation while promoting differentiation. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. Involved in the regulation of GLUT1 expression and basal glucose uptake in L6 myotubes; and negatively regulates GLUT4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C- Jun phosphorylation is stimulated by p38-alpha and inhibited by p38-gamma, leading to a distinct AP-1 regulation. Required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. Positively regulates the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. Its expression is down-regulation by p38-alpha activation. Highly expressed in skeletal muscle and heart.

Protein type: Protein kinase, CMGC; EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CMGC group; MAPK family; p38 subfamily; MAPK/p38 subfamily

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol

Molecular Function: MAP kinase activity; protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding

Biological Process: mitochondrion organization and biogenesis; muscle development; nerve growth factor receptor signaling pathway; DNA damage induced protein phosphorylation; transcription, DNA-dependent; organelle organization and biogenesis; MAPKKK cascade; signal transduction; myoblast differentiation; peptidyl-serine phosphorylation; muscle cell differentiation; regulation of transcription, DNA-dependent; Ras protein signal transduction; positive regulation of muscle cell differentiation; cell cycle arrest; vascular endothelial growth factor receptor signaling pathway
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 Research Articles on ERK    1. Thus, in endothelial cells p38alpha mediates apoptotic signaling, whereas p38beta and p38gamma transduce survival signaling
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ERK elisa kitPathways associated with ERK elisa kit
 Reference Product  PubMed Publications
 DUSP1 elisa kit  >1 publications with ERK and DUSP1
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 DSCAM Interactions Pathway antibodies  DSCAM Interactions Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
Diseases associated with ERK elisa kitOrgans/Tissues associated with ERK elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with ERK and Neoplasms
 Inflammation Antibodies  >3 publications with ERK and Inflammation
 Gastrointestinal Diseases Antibodies  >2 publications with ERK and Gastrointestinal Diseases
 Disease Models, Animal Antibodies  >1 publications with ERK and Disease Models, Animal
 Learning Disorders Antibodies  >1 publications with ERK and Learning Disorders
 Carcinoma Antibodies  >1 publications with ERK and Carcinoma
 Breast Neoplasms Antibodies  >1 publications with ERK and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with ERK and Brain
 Uterus Antibodies  >1 publications with ERK and Uterus
 Mammary Gland Antibodies  >1 publications with ERK and Mammary Gland
 Muscle Antibodies  >1 publications with ERK and Muscle
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