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CASR elisa kit :: Human Extracellular calcium sensing receptor (CASR) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7243649 CASR elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Extracellular calcium sensing receptor (CASR), ELISA Kit

 Also Known As   

Human Extracellular calcium sensing receptor (CASR) ELISA Kit

 Product Gene Name   

CASR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene+612899
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 Species Reactivity    Human
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Detection Range    1.0-25ng/mL
 Sensitivity    0.1ng/mL
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of CASR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for CASR purchase    MBS7243649 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Extracellular calcium sensing receptor (CASR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1.0-25ng/mL in biological research samples containing CASR, with an estimated sensitivity of 0.1ng/mL. The ELISA analytical biochemical technique of the MBS7243649 kit is based on CASR antibody-CASR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CASR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CASR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for CASR elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for CASR. It may not necessarily be applicable to this product.
 NCBI GI #    37577159
 NCBI GeneID    846
 NCBI Accession #    NP_000379.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000388.3 [Other Products]
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 UniProt Secondary Accession #    Q13912; Q16108; Q16109; Q16110; Q16379; Q2M1T0; Q4PJ19 [Other Products]
 UniProt Related Accession #    P41180 [Other Products]
 Molecular Weight    121,772 Da
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 NCBI Official Full Name    extracellular calcium-sensing receptor isoform 2
 NCBI Official Synonym Full Names    calcium-sensing receptor
 NCBI Official Symbol    CASR [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    extracellular calcium-sensing receptor; parathyroid Ca(2+)-sensing receptor 1; parathyroid cell calcium-sensing receptor 1
 UniProt Protein Name    Extracellular calcium-sensing receptor
 UniProt Synonym Protein Names   
Parathyroid cell calcium-sensing receptor 1; PCaR1
 Protein Family    Extracellular calcium-sensing receptor
 UniProt Gene Name    CASR [Similar Products]
 UniProt Synonym Gene Names    GPRC2A; PCAR1; CaSR; PCaR1 [Similar Products]
 UniProt Entry Name    CASR_HUMAN
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 NCBI Summary for CASR    The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CASR    CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Receptor, GPCR; GPCR, family 3; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; phosphoinositide phospholipase C activity

Biological Process: cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; ossification; anatomical structure morphogenesis; metabolic process; chemosensory behavior; detection of calcium ion

Disease: Hypocalciuric Hypercalcemia, Familial, Type I; Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1
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 Research Articles on CASR    1. A novel functional role for RAMP1 in regulation of CaSR signalling in addition to its known role in receptor trafficking, is reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CASR elisa kitPathways associated with CASR elisa kit
 Reference Product  PubMed Publications
 PTH elisa kit  >227 publications with CASR and PTH
 NPSR1 elisa kit  >1 publications with CASR and NPSR1
 Products by Pathway  Pathway Diagram
 Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies  Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
 E-cadherin Signaling In Keratinocytes Pathway antibodies  E-cadherin Signaling In Keratinocytes Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies  GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with CASR elisa kitOrgans/Tissues associated with CASR elisa kit
 Disease Name  Pubmed Publications
 Hyperparathyroidism Antibodies  >226 publications with CASR and Hyperparathyroidism
 Hypercalcemia Antibodies  >193 publications with CASR and Hypercalcemia
 Hypocalcemia Antibodies  >117 publications with CASR and Hypocalcemia
 Kidney Diseases Antibodies  >91 publications with CASR and Kidney Diseases
 Hypoparathyroidism Antibodies  >76 publications with CASR and Hypoparathyroidism
 Hyperparathyroidism, Secondary Antibodies  >74 publications with CASR and Hyperparathyroidism, Secondary
 Hypertension Antibodies  >38 publications with CASR and Hypertension
 Renal Insufficiency Antibodies  >22 publications with CASR and Renal Insufficiency
 Brain Diseases Antibodies  >22 publications with CASR and Brain Diseases
 Hypocalciuric hypercalcemia, familial, type 1 Antibodies  >20 publications with CASR and Hypocalciuric hypercalcemia, familial, type 1
 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >382 publications with CASR and Parathyroid
 Kidney Antibodies  >231 publications with CASR and Kidney
 Liver Antibodies  >33 publications with CASR and Liver
 Pancreas Antibodies  >19 publications with CASR and Pancreas
 Eye Antibodies  >1 publications with CASR and Eye
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