NP_036436.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
F-box/LRR-repeat protein 7 isoform 1
NCBI Official Synonym Full Names
F-box and leucine-rich repeat protein 7
NCBI Official Synonym Symbols
NCBI Protein Information
F-box/LRR-repeat protein 7; F-box protein Fbl7
UniProt Protein Name
F-box/LRR-repeat protein 7
UniProt Synonym Protein Names
F-box and leucine-rich repeat protein 7; F-box protein FBL6/FBL7
UniProt Synonym Gene Names
UniProt Entry Name
FBXL7_HUMAN
NCBI Summary for FBXL7
This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
UniProt Comments for FBXL7
FBXL7: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest. Belongs to the FBXL7 family.
Chromosomal Location of Human Ortholog: 5p15.1
Cellular Component: centrosome; cytoplasm; SCF ubiquitin ligase complex; ubiquitin ligase complex
Molecular Function: ubiquitin-protein ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; cell proliferation; mitosis; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; protein ubiquitination; G2/M transition of mitotic cell cycle
Research Articles on FBXL7
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Diseases associated with FBXL7 elisa kit
Organs/Tissues associated with FBXL7 elisa kit
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