P0C2W1.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
F-box/SPRY domain-containing protein 1
NCBI Official Synonym Full Names
F-box protein 45
NCBI Official Synonym Symbols
NCBI Protein Information
F-box/SPRY domain-containing protein 1; hFbxo45; F-box only protein 45
UniProt Protein Name
F-box/SPRY domain-containing protein 1
UniProt Synonym Protein Names
F-box only protein 45; hFbxo45
UniProt Synonym Gene Names
UniProt Entry Name
FBSP1_HUMAN
NCBI Summary for FBXO45
Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]
UniProt Comments for FBXO45
FBXO45: Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Plays a role in the regulation of neurotransmission at mature neurons. May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation. Belongs to the FBXO45/Fsn family.
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: presynaptic membrane; postsynaptic membrane; postsynaptic density; cell junction
Molecular Function: protein binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; anterior commissure morphogenesis; cerebral cortex tangential migration; protein ubiquitination during ubiquitin-dependent protein catabolic process; neuron migration; protein ubiquitination; cerebral cortex radially oriented cell migration; corticospinal tract morphogenesis; response to DNA damage stimulus
Research Articles on FBXO45
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Organs/Tissues associated with FBXO45 elisa kit
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