NP_036296.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
F-box/WD repeat-containing protein 2
NCBI Official Synonym Full Names
F-box and WD repeat domain containing 2
NCBI Protein Information
F-box/WD repeat-containing protein 2; F-box and WD-40 domain protein 2; F-box and WD-40 domain-containing protein 2
UniProt Protein Name
F-box/WD repeat-containing protein 2
UniProt Synonym Protein Names
F-box and WD-40 domain-containing protein 2; Protein MD6
UniProt Synonym Gene Names
UniProt Entry Name
FBXW2_HUMAN
NCBI Summary for FBXW2
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
UniProt Comments for FBXW2
FBXW2: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: cytoplasm
Molecular Function: protein binding; ubiquitin-protein ligase activity
Biological Process: protein ubiquitination; protein modification process; proteolysis
Research Articles on FBXW2
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Products associated with FBXW2 elisa kit
Pathways associated with FBXW2 elisa kit
Diseases associated with FBXW2 elisa kit
Organs/Tissues associated with FBXW2 elisa kit
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