O60907.3
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
F-box-like/WD repeat-containing protein TBL1X
NCBI Official Synonym Full Names
transducin (beta)-like 1X-linked
NCBI Protein Information
F-box-like/WD repeat-containing protein TBL1X; transducin beta-like protein 1X; transducin-beta-like protein 1, X-linked
UniProt Protein Name
F-box-like/WD repeat-containing protein TBL1X
UniProt Synonym Protein Names
SMAP55; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked
UniProt Synonym Gene Names
UniProt Entry Name
TBL1X_HUMAN
NCBI Summary for TBL1X
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008]
UniProt Comments for TBL1X
TBL1X: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. Belongs to the WD repeat EBI family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: Xp22.3
Cellular Component: nucleoplasm; transcriptional repressor complex; spindle microtubule; histone deacetylase complex; nucleus
Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; histone binding; beta-catenin binding; transcription factor binding; transcription corepressor activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; establishment and/or maintenance of chromatin architecture; Notch signaling pathway; sensory perception of sound; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; histone deacetylation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; cellular lipid metabolic process; proteolysis
Research Articles on TBL1X
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Organs/Tissues associated with TBL1X elisa kit
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