NP_001245381.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
F-box only protein 18 isoform 3
NCBI Official Synonym Full Names
F-box protein, helicase, 18
NCBI Official Synonym Symbols
NCBI Protein Information
F-box only protein 18; F-box DNA helicase 1; F-box only protein, helicase, 18
UniProt Protein Name
F-box only protein 18
UniProt Synonym Protein Names
F-box DNA helicase 1
UniProt Synonym Gene Names
UniProt Entry Name
FBX18_HUMAN
NCBI Summary for FBXO18
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for FBXO18
FBXO18: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction. Belongs to the helicase family. UvrD subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Helicase; EC 3.6.4.12
Chromosomal Location of Human Ortholog: 10p15.1
Cellular Component: nucleus
Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; ATP binding
Biological Process: positive regulation of protein amino acid phosphorylation; DNA catabolic process, endonucleolytic; DNA duplex unwinding
Research Articles on FBXO18
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