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FBXO31 elisa kit :: Human F box only protein 31 (FBXO31) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7229420 FBXO31 elisa kit
Unit / Price
48-Strip-Wells  /  $455 +1 FREE 8GB USB
96-Strip-Wells  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

F box only protein 31 (FBXO31), ELISA Kit

 Also Known As   

Human F box only protein 31 (FBXO31) ELISA Kit

 Product Gene Name   

FBXO31 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    609102
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 Species Reactivity    Human
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Competitive
 Detection Range    0.5-10ng/mL
 Sensitivity    0.1ng/mL
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FBXO31 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FBXO31 purchase    MBS7229420 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the F box only protein 31 (FBXO31) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.5-10ng/mL in biological research samples containing FBXO31, with an estimated sensitivity of 0.1ng/mL. The ELISA analytical biochemical technique of the MBS7229420 kit is based on FBXO31 antibody-FBXO31 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FBXO31 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FBXO31. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for FBXO31 elisa kit    Epigenetics and Nuclear Signaling
NCBI/Uniprot data below describe general gene information for FBXO31. It may not necessarily be applicable to this product.
 NCBI GI #    83035136
 NCBI GeneID    79791
 NCBI Accession #    NP_079011.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_024735.4 [Other Products]
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 UniProt Secondary Accession #    Q5K680; Q8WYV1; Q96D73; Q9UFV4 [Other Products]
 UniProt Related Accession #    Q5XUX0 [Other Products]
 Molecular Weight    49,039 Da [Similar Products]
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 NCBI Official Full Name    F-box only protein 31 isoform 1
 NCBI Official Synonym Full Names    F-box protein 31
 NCBI Official Symbol    FBXO31 [Similar Products]
 NCBI Official Synonym Symbols   
FBX14; Fbx31; MRT45; FBXO14; pp2386
[Similar Products]
 NCBI Protein Information    F-box only protein 31; SCF ubiquitin ligase specificity factor; putative breast cancer tumor-suppressor
 UniProt Protein Name    F-box only protein 31
 Protein Family    F-box only protein
 UniProt Gene Name    FBXO31 [Similar Products]
 UniProt Synonym Gene Names    FBX14; FBX31; PP2386 [Similar Products]
 UniProt Entry Name    FBX31_HUMAN
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 NCBI Summary for FBXO31    This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
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 UniProt Comments for FBXO31    FBXO31: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. By DNA damage. Increases after UV irradiation, X-ray irradiation, oxidative stress (H(2)O(2)) or addition of the chemotherapeutic DNA-damaging agents etoposide, adriamycin, cisplatin or fluorouracil. Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. Belongs to the FBXO31 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 16q24.2

Cellular Component: cell soma; SCF ubiquitin ligase complex

Molecular Function: cyclin binding

Biological Process: G1 DNA damage checkpoint; cyclin catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; response to DNA damage stimulus

Disease: Mental Retardation, Autosomal Recessive 45
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 Research Articles on FBXO31    1. Truncation of the E3 ubiquitin ligase component FBXO31 causes non-syndromic autosomal recessive intellectual disability.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FBXO31 elisa kitDiseases associated with FBXO31 elisa kit
 Reference Product  PubMed Publications
 SKP1 elisa kit  >5 publications with FBXO31 and SKP1
 CUL1 elisa kit  >2 publications with FBXO31 and CUL1
 RBX1 elisa kit  >1 publications with FBXO31 and RBX1
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >3 publications with FBXO31 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with FBXO31 and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >1 publications with FBXO31 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with FBXO31 and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >1 publications with FBXO31 and Disease Models, Animal
 Liver Diseases Antibodies  >1 publications with FBXO31 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with FBXO31 and Liver Neoplasms
Organs/Tissues associated with FBXO31 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with FBXO31 and Kidney
 Prostate Antibodies  >2 publications with FBXO31 and Prostate
 Adrenal Gland Antibodies  >1 publications with FBXO31 and Adrenal Gland
 Liver Antibodies  >1 publications with FBXO31 and Liver
 Embryonic Tissue Antibodies  >1 publications with FBXO31 and Embryonic Tissue
 Eye Antibodies  >1 publications with FBXO31 and Eye
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