NP_079011.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
F-box only protein 31 isoform 1
NCBI Official Synonym Full Names
F-box protein 31
NCBI Official Synonym Symbols
FBX14; Fbx31; MRT45; FBXO14; pp2386 [Similar Products]
NCBI Protein Information
F-box only protein 31; SCF ubiquitin ligase specificity factor; putative breast cancer tumor-suppressor
UniProt Protein Name
F-box only protein 31
UniProt Synonym Gene Names
UniProt Entry Name
FBX31_HUMAN
NCBI Summary for FBXO31
This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Comments for FBXO31
FBXO31: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. By DNA damage. Increases after UV irradiation, X-ray irradiation, oxidative stress (H(2)O(2)) or addition of the chemotherapeutic DNA-damaging agents etoposide, adriamycin, cisplatin or fluorouracil. Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. Belongs to the FBXO31 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 16q24.2
Cellular Component: cell soma; SCF ubiquitin ligase complex
Molecular Function: cyclin binding
Biological Process: G1 DNA damage checkpoint; cyclin catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; response to DNA damage stimulus
Disease: Mental Retardation, Autosomal Recessive 45
Research Articles on FBXO31
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Diseases associated with FBXO31 elisa kit
Organs/Tissues associated with FBXO31 elisa kit
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