NP_001229392.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,804 Da
NCBI Official Full Name
F-box only protein 32 isoform 3
NCBI Official Synonym Full Names
F-box protein 32
NCBI Official Synonym Symbols
NCBI Protein Information
F-box only protein 32; atrogin 1; atrogin-1; muscle atrophy F-box protein
UniProt Protein Name
F-box only protein 32
UniProt Synonym Protein Names
Atrogin-1; Muscle atrophy F-box protein; MAFbx
UniProt Synonym Gene Names
UniProt Entry Name
FBX32_HUMAN
NCBI Summary for FBXO32
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
UniProt Comments for FBXO32
FBXO32: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component: nucleolus; Z disc
Molecular Function: protein binding
Biological Process: protein ubiquitination; response to denervation involved in regulation of muscle adaptation
Research Articles on FBXO32
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Products associated with FBXO32 elisa kit
Pathways associated with FBXO32 elisa kit
Diseases associated with FBXO32 elisa kit
Organs/Tissues associated with FBXO32 elisa kit
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