NP_001135994.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
F-box only protein 5 isoform b
NCBI Official Synonym Full Names
F-box protein 5
NCBI Protein Information
F-box only protein 5; F-box protein Fbx5; early mitotic inhibitor 1
UniProt Protein Name
F-box only protein 5
UniProt Synonym Protein Names
Early mitotic inhibitor 1
UniProt Synonym Gene Names
UniProt Entry Name
FBX5_HUMAN
NCBI Summary for FBXO5
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]
UniProt Comments for FBXO5
FBX5: a member of the SCFs class of F-box proteins. F-box proteins constitute one of the subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. FBX5 is an early mitotic inhibitor-1 (Emi1) that interacts with Cdc20 and inhibits the anaphase promoting complex (APC/C). APC/C is a ubiquitin ligase that targets mitotic regulatory proteins for degradation. FBX5 accumulates in the S phase and is rapidly degraded in prometaphase.
Chromosomal Location of Human Ortholog: 6q25.2
Cellular Component: nucleoplasm; cytoplasm; spindle; cytosol; nucleus
Molecular Function: protein binding; metal ion binding; protein kinase binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; vesicle organization and biogenesis; regulation of mitotic cell cycle; oocyte maturation; G1/S-specific transcription in mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of meiosis; mitotic cell cycle; mitotic metaphase/anaphase transition; spindle assembly involved in female meiosis I; microtubule polymerization; G1/S transition of mitotic cell cycle
Research Articles on FBXO5
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Products associated with FBXO5 elisa kit
Pathways associated with FBXO5 elisa kit
Diseases associated with FBXO5 elisa kit
Organs/Tissues associated with FBXO5 elisa kit
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